Oxidative Medicine and Cellular Longevity

Nitric Oxide: A Regulator of Cellular Function in Health and Disease


Publishing date
30 Oct 2015
Status
Published
Submission deadline
12 Jun 2015

Lead Editor

1University of Leicester, Leicester, UK

2University of Wollongong, Wollongong, Australia

3Pontificia Universidad Católica de Chile, Santiago, Chile

4University of Guelph, Guelph, Canada


Nitric Oxide: A Regulator of Cellular Function in Health and Disease

Description

Nitric oxide (NO) is a gaseous messenger molecule synthesized from L-arginine and molecular oxygen by three different NO synthases (neuronal (n), endothelial (e), and inducible (i) NOS). Many reports suggest that excessive and abnormal production of NO plays a crucial role in neuronal cell death including neurodegenerative disorders such as Alzheimer’s and Parkinson’s diseases, as well as various conditions of vascular dysfunction. In contrast, numerous lines of evidence indicate that NO is essential for cellular function, differentiation, and survival. In general, NO can modulate cell function through signalling pathways that include the NO/cyclic guanosine monophosphate (cGMP) pathway and the S-nitrosylation pathway in which NO reversibly binds to thiol groups of proteins thereby modulating their function or through NO-associated acetylation/deacetylation or methylation/demethylation networks. In addition, NO can further modulate cell function through peroxynitrite formation leading to nitrotyrosination of protein residues, as well as through modulation of gene expression via epigenetic changes, including direct modulation of transcription factor activity. How controlled S-nitrosylation/nitrotyrosination of proteins and activation of the NO/cGMP signalling pathway promote cellular survival and induce epigenetic changes while uncontrolled signalling promotes cell death and dysfunction remains to be elucidated.

We invite investigators to contribute original research articles and review articles that address the continuing efforts to understand the molecular mechanisms underlying nitrergic signalling in vascular or neural function in healthy and diseased states. In particular, we are interested in articles describing the functional effects of posttranslational protein modifications induced by NO signalling such as S-nitrosylation or 3-nitrotyrosination.

Potential topics include, but are not limited to:

  • Nitric oxide signalling at the synapse
  • S-nitrosylation of cellular proteins and modulation of function
  • 3-nitrotyrosination as a mediator of neurodegeneration or other neurological disorders
  • Posttranslational modification by NO
  • NO-mediated regulation of vascular function
  • NO/NOS and arginase balance in endothelial dysfunction
  • NO and regulation of gene expression/epigenetics

Articles

  • Special Issue
  • - Volume 2016
  • - Article ID 9782346
  • - Editorial

Nitric Oxide: A Regulator of Cellular Function in Health and Disease

Luis Sobrevia | Lezanne Ooi | ... | Joern R. Steinert
  • Special Issue
  • - Volume 2016
  • - Article ID 8548910
  • - Research Article

An Abnormal Nitric Oxide Metabolism Contributes to Brain Oxidative Stress in the Mouse Model for the Fragile X Syndrome, a Possible Role in Intellectual Disability

Elena Lima-Cabello | Francisco Garcia-Guirado | ... | Yolanda de Diego-Otero
  • Special Issue
  • - Volume 2016
  • - Article ID 4867124
  • - Review Article

Nitroxyl (HNO): A Reduced Form of Nitric Oxide with Distinct Chemical, Pharmacological, and Therapeutic Properties

Mai E. Shoman | Omar M. Aly
  • Special Issue
  • - Volume 2016
  • - Article ID 8262383
  • - Research Article

Training Status as a Marker of the Relationship between Nitric Oxide, Oxidative Stress, and Blood Pressure in Older Adult Women

André Mourão Jacomini | Hugo Celso Dutra de Souza | ... | Anderson Saranz Zago
  • Special Issue
  • - Volume 2016
  • - Article ID 5346327
  • - Review Article

Role for Tetrahydrobiopterin in the Fetoplacental Endothelial Dysfunction in Maternal Supraphysiological Hypercholesterolemia

Andrea Leiva | Bárbara Fuenzalida | ... | Luis Sobrevia
  • Special Issue
  • - Volume 2016
  • - Article ID 3806157
  • - Review Article

Getting to NO Alzheimer’s Disease: Neuroprotection versus Neurotoxicity Mediated by Nitric Oxide

Rachelle Balez | Lezanne Ooi
  • Special Issue
  • - Volume 2016
  • - Article ID 5681036
  • - Review Article

Nitric Oxide-Mediated Posttranslational Modifications: Impacts at the Synapse

Sophie A. Bradley | Joern R. Steinert
  • Special Issue
  • - Volume 2015
  • - Article ID 157876
  • - Research Article

Selective Nitric Oxide Synthase Inhibitor 7-Nitroindazole Protects against Cocaine-Induced Oxidative Stress in Rat Brain

Vessela Vitcheva | Rumyana Simeonova | ... | Mitka Mitcheva
Oxidative Medicine and Cellular Longevity
 Journal metrics
Acceptance rate44%
Submission to final decision76 days
Acceptance to publication39 days
CiteScore4.520
Impact Factor4.868
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