Oxidative Medicine and Cellular Longevity

Biomarkers of Aging: From Cellular Senescence to Age-Associated Diseases

Publishing date
03 Feb 2017
Submission deadline
16 Sep 2016

1University of Porto, Porto, Portugal

2Martin Luther University Halle-Wittenberg, Halle (Saale), Germany

3University of Cambridge, Cambridge, UK

Biomarkers of Aging: From Cellular Senescence to Age-Associated Diseases


The aging process results from accumulation of molecular damage and impairment of signalling pathways that affect not only single cells but also organs and whole individuals. Besides physiological modifications along time, the aging phenotype can be accelerated by metabolic dysfunction. Aging and metabolic dysfunction phenotypes share biomarkers as well as initial and progression mechanisms.

We invite authors to submit original research and review articles (in vitro, animal, and/or clinical studies) for publishing in this special issue, focused not only on individual hallmarks of senescent cells, responses to age-related damage, aging phenotype, and age-associated diseases but also on their sequential evolution and interconnection. Studies on metabolic dysfunction contribution to the earlier development of aging features as well as counteracting strategies could also be considered for submission.

Potential topics include, but are not limited to:

  • Cellular biomarkers of aging:
    • Gene expression and epigenetic regulation
    • Posttranslational modification and proteostasis loss
    • Mitochondrial dysfunction and disruption of redox signalling
    • Cellular senescence, genomic instability, and telomere attrition
  • Organ and peripheral biomarkers of aging:
    • The immune system and aging (autoimmune responses, immunological memory, and chronic low-grade inflammation)
    • Early developmental (epigenetic) programming of aging and modulation by the environment
    • Premature aging associated with insulin resistance
    • Aging and cardiovascular, neurodegenerative, and cognitive impairment disease risk
  • Antiaging strategies:
    • Antiaging nutrients and energy restriction mimetics


  • Special Issue
  • - Volume 2017
  • - Article ID 7280690
  • - Editorial

Biomarkers of Aging: From Cellular Senescence to Age-Associated Diseases

Maria João Martins | Miguel Constância | ... | Andreas Simm
  • Special Issue
  • - Volume 2017
  • - Article ID 3793817
  • - Research Article

Resveratrol Attenuates Copper-Induced Senescence by Improving Cellular Proteostasis

Liliana Matos | Alexandra Monteiro Gouveia | Henrique Almeida
  • Special Issue
  • - Volume 2017
  • - Article ID 6487825
  • - Research Article

Long-Term Treatment of Native LDL Induces Senescence of Cultured Human Endothelial Cells

Sung-Tack Oh | Hoon Park | ... | Sung Yeul Yang
  • Special Issue
  • - Volume 2017
  • - Article ID 9270549
  • - Review Article

Is p53 Involved in Tissue-Specific Insulin Resistance Formation?

Justyna Strycharz | Jozef Drzewoski | ... | Agnieszka Sliwinska
  • Special Issue
  • - Volume 2017
  • - Article ID 7928981
  • - Research Article

Impact of Yoga and Meditation on Cellular Aging in Apparently Healthy Individuals: A Prospective, Open-Label Single-Arm Exploratory Study

Madhuri Tolahunase | Rajesh Sagar | Rima Dada
  • Special Issue
  • - Volume 2017
  • - Article ID 6469138
  • - Review Article

Nutritional and Lifestyle Interventions for Age-Related Macular Degeneration: A Review

Ângela Carneiro | José Paulo Andrade
  • Special Issue
  • - Volume 2016
  • - Article ID 2069290
  • - Research Article

Serum from Varicose Patients Induces Senescence-Related Dysfunction of Vascular Endothelium Generating Local and Systemic Proinflammatory Conditions

Justyna Mikuła-Pietrasik | Paweł Uruski | ... | Krzysztof Książek
Oxidative Medicine and Cellular Longevity
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