Trauma repair is a complex process involving multiple pathophysiological mechanisms, in which oxidative stress is one of the important mechanisms. Oxidative stress occurs at the beginning of trauma and accompanies the whole process of trauma repair. Excessive oxidative stress causes damage to lipids, proteins, and DNA, leading to cell necrosis and apoptosis, thus affecting trauma repair.

Trauma repair includes three processes: inflammatory response, cell proliferation, and tissue remodeling. Various mediators and growth factors are involved in this process. The factors that interfere with the regulation of trauma repair can hinder the process of trauma repair. Recently, the research directions of trauma have mainly focused on the four aspects: the mechanism of occurrence and prevention of systemic damage; repair and regeneration of tissue injury, with a focus on the molecular mechanism of trauma repair of important tissues (skin, lung, bone, nerve, etc.) and stem cells in tissue repair; the key technologies and transformation of treatment of major injuries; and the development of trauma rescue equipment and new drugs in the treatment of trauma. The study of the molecular mechanism of trauma repair is essential for drug development and strategy selection. In the past 15 years, the research of trauma repair has gradually changed from the pursuit of healing speed to the quality of healing and has paid more attention to functional recovery and tissue reconstruction.

This Special Issue will focus on the research of the regulatory role of oxidative stress in the process of trauma repair. It is hoped that the research of this Special Issue will improve the regulatory theoretical system of trauma repair, and provide more targets related to oxidative stress. Original research and review articles are welcome.

Potential topics include but are not limited to the following:

• The regulatory role of oxidative stress in spinal cord injury
• The regulatory effect of oxidative stress in peripheral nerve injury
• The regulatory molecular mechanism of oxidative stress during traumatic brain injury recovery
• Therapeutic effect of antioxidants on nerve injury repair
• The effect of oxidative stress on wound repair
• Therapeutic effect of antioxidants on wound repair