Oxidative Medicine and Cellular Longevity

Oxidative Stress and Autophagy in Metabolism and Longevity


Status
Published

Lead Editor

1University of Iowa, Iowa City, USA

2Baylor College of Medicine, Houston, USA

3National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, India

4Texas A&M Health Science Center, Houston, USA

5Yale University, New Haven, USA


Oxidative Stress and Autophagy in Metabolism and Longevity

Description

Autophagy is a conserved dynamic catabolic process, in which nonfunctional macromolecules and cellular organelles are engulfed, degraded, and recycled, and thereby it plays a crucial role in maintaining cellular homeostasis. A basal level of reactive oxygen species (ROS) is essential for the cell signaling and survival, but their elevated levels have been attributed to multiple pathologies and ageing. ROS induced oxidation is the primary mechanism through which cellular macromolecules accumulate damage over a period of time. Oxidative stress has long been identified to play a central role in the progression of cellular senescence and diabetes. The imbalance in the ROS production has been noted to immediately follow the nutrient deprivation and therefore it represents an important mediator of the autophagy. The cellular organelles such as mitochondria, peroxisome, and endoplasmic reticulum play a critical role in the cellular metabolism and remain at higher risk of accumulating oxidative damage.

In this special issue we invite investigators to contribute their original research, both in vitro and in vivo studies, and/or review article to broaden our understanding of the link between oxidative stress and autophagy process and their role in the regulation of cellular longevity and pathogenesis of metabolic disorders.

Potential topics include, but are not limited to:

  • Oxidative stress and autophagy in regulation of longevity and/or metabolism
  • Targeting autophagy pathway in diabetes
  • Autophagy of cellular organelles such as mitochondria and peroxisome in the regulation of cellular longevity and/or metabolic disorder such as diabetes
  • Identification of biomarkers allowing monitoring of physiological or pathophysiological events regulating progression of metabolic disorders and/or longevity
  • Role of autophagy and oxidant signaling in the nutrient deprivation/caloric restriction mediated beneficial effects in metabolic disorders and ageing
  • Selective autophagy in regulation of cellular longevity

Articles

  • Special Issue
  • - Volume 2017
  • - Article ID 3451528
  • - Editorial

Oxidative Stress and Autophagy in Metabolism and Longevity

Ajit Vikram | Ramakrishnan Anish | ... | Ravinder K. Kaundal
  • Special Issue
  • - Volume 2017
  • - Article ID 4962950
  • - Research Article

Parental High-Fat Diet Promotes Inflammatory and Senescence-Related Changes in Prostate

Kulbhushan Tikoo | Ajit Vikram | ... | Richa Chhabra
  • Special Issue
  • - Volume 2017
  • - Article ID 8498510
  • - Research Article

Decreased Tissue COX5B Expression and Mitochondrial Dysfunction during Sepsis-Induced Kidney Injury in Rats

Jochen Hinkelbein | Lennert Böhm | ... | Fabrizio Cirillo
  • Special Issue
  • - Volume 2016
  • - Article ID 9591482
  • - Research Article

CLOCK Promotes Endothelial Damage by Inducing Autophagy through Reactive Oxygen Species

Xiao Tang | Changpo Lin | ... | Longhua Fan
  • Special Issue
  • - Volume 2016
  • - Article ID 4313204
  • - Research Article

PTEN Activation by DNA Damage Induces Protective Autophagy in Response to Cucurbitacin B in Hepatocellular Carcinoma Cells

Yanan Niu | Wen Sun | ... | Xiuping Chen
  • Special Issue
  • - Volume 2016
  • - Article ID 4085727
  • - Research Article

Coordinated Upregulation of Mitochondrial Biogenesis and Autophagy in Breast Cancer Cells: The Role of Dynamin Related Protein-1 and Implication for Breast Cancer Treatment

Peng Zou | Longhua Liu | ... | Zhiyong Cheng
  • Special Issue
  • - Volume 2016
  • - Article ID 1810289
  • - Research Article

Altered Striatocerebellar Metabolism and Systemic Inflammation in Parkinson’s Disease

Chiun-Chieh Yu | Meng-Hsiang Chen | ... | Wei-Che Lin
  • Special Issue
  • - Volume 2016
  • - Article ID 4856431
  • - Research Article

Thioredoxin Binding Protein-2 Regulates Autophagy of Human Lens Epithelial Cells under Oxidative Stress via Inhibition of Akt Phosphorylation

Jiaojie Zhou | Ke Yao | ... | Yibo Yu
Oxidative Medicine and Cellular Longevity
 Journal metrics
Acceptance rate48%
Submission to final decision56 days
Acceptance to publication37 days
CiteScore7.300
Impact Factor5.076
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