Oxidative Medicine and Cellular Longevity

Pathological Consequences of Drug Abuse: Implication of Redox Imbalance


Publishing date
01 Jul 2019
Status
Published
Submission deadline
01 Mar 2019

1University of Foggia, Foggia, Italy

2University of Ferrara, Ferrara, Italy

3North-West University, Potchefstroom, South Africa


Pathological Consequences of Drug Abuse: Implication of Redox Imbalance

Description

Drug abuse has been shown to increase the risk of developing different pathological conditions, such as mental disorders and infectious and pulmonary diseases as well as cardiovascular failure. With respect to drug abuse-related psychiatric conditions, it has been also demonstrated that subjects already suffering from mental illnesses are particularly vulnerable to drug abuse and addiction and that, conversely, chronic drug abuse often makes these psychiatric conditions more severe and difficult to treat.

Redox imbalance, defined as a disequilibrium between reactive oxygen species (ROS) generating and degrading systems, has recently gained great importance as crucial pathogenetic element in the impact of drug abuse on health. Moreover, increased oxidative stress has been also proposed as a reliable biomarker to be used in clinics for the identification of the “risk state” to develop mental, infectious, respiratory, or cardiovascular disorders following the abuse of psychoactive compounds.

This special issue will include original research articles and reviews on recent preclinical and clinical findings about the role of redox dysregulation in the onset and progression of drug-induced disorders, with a particular focus on the possibility of developing more targeted pharmacological interventions for them.

Potential topics include but are not limited to the following:

  • Role of redox imbalance (in terms of free radical production by mitochondria, NADPH oxidase NOX enzymes-derived oxidative stress, impaired SOD, and glutathione system activity) in the pathogenesis of drug-induced mental diseases
  • Role of redox imbalance in the pathogenesis of infectious illnesses associated with chronic use of psychoactive compounds
  • Role of redox imbalance in the development of drug abuse-related respiratory disorders
  • Role of redox imbalance in the onset and progression of cardiovascular failure following addictive behaviors
  • The use of antioxidant compounds or molecules inhibiting specific ROS producing enzymatic systems in the treatment of medical conditions resulting from drug abuse
  • Redox imbalance as biomarker to identify the “risk state” to develop a specific disorder following the use of psychoactive compounds
  • Role of redox imbalance in the pathological consequences of emerging drugs of abuse

Articles

  • Special Issue
  • - Volume 2019
  • - Article ID 4780852
  • - Editorial

Pathological Consequences of Drug Abuse: Implication of Redox Imbalance

Stefania Schiavone | Margherita Neri | Brian H. Harvey
  • Special Issue
  • - Volume 2019
  • - Article ID 2415243
  • - Research Article

Aerobic Physical Exercise as a Neuroprotector Strategy for Ethanol Binge-Drinking Effects in the Hippocampus and Systemic Redox Status in Rats

Dinair Pamplona-Santos | Kátia Lamarão-Vieira | ... | Rafael Rodrigues Lima
  • Special Issue
  • - Volume 2019
  • - Article ID 9417048
  • - Research Article

Buprenorphine and Methadone as Opioid Maintenance Treatments for Heroin-Addicted Patients Induce Oxidative Stress in Blood

Christonikos Leventelis | Nikolaos Goutzourelas | ... | Demetrios Kouretas
  • Special Issue
  • - Volume 2019
  • - Article ID 5452727
  • - Research Article

“Special K” Drug on Adolescent Rats: Oxidative Damage and Neurobehavioral Impairments

Sabrina de Carvalho Cartágenes | Luanna Melo Pereira Fernandes | ... | Cristiane Socorro Ferraz Maia
  • Special Issue
  • - Volume 2018
  • - Article ID 6124745
  • - Research Article

mTOR Modulates Methamphetamine-Induced Toxicity through Cell Clearing Systems

Gloria Lazzeri | Francesca Biagioni | ... | Francesco Fornai
  • Special Issue
  • - Volume 2018
  • - Article ID 3467531
  • - Research Article

Repeated Cycles of Binge-Like Ethanol Intake in Adolescent Female Rats Induce Motor Function Impairment and Oxidative Damage in Motor Cortex and Liver, but Not in Blood

Luanna Melo Pereira Fernandes | Klaylton Sousa Lopes | ... | Cristiane Socorro Ferraz Maia
  • Special Issue
  • - Volume 2018
  • - Article ID 4982453
  • - Review Article

Epigenetic Effects Induced by Methamphetamine and Methamphetamine-Dependent Oxidative Stress

Fiona Limanaqi | Stefano Gambardella | ... | Francesco Fornai
Oxidative Medicine and Cellular Longevity
 Journal metrics
Acceptance rate48%
Submission to final decision56 days
Acceptance to publication37 days
CiteScore7.300
Impact Factor5.076
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