Oxidative Medicine and Cellular Longevity

Oxidative Stress in Aging Brain: Nutritional and Pharmacological Interventions for Neurodegenerative Disorders


Status
Published

1Universita del Salento, Lecce, Italy

2University of Lille 1, Lille, France

3University of Foggia, Foggia, Italy


Oxidative Stress in Aging Brain: Nutritional and Pharmacological Interventions for Neurodegenerative Disorders

Description

The interactions between lifestyle and brain health have been widely demonstrated and recent studies have demonstrated the important role of antioxidants and vitamins in the antiaging process and in neurodegenerative disorders such as Alzheimer’s and Parkinson’s diseases.

It has been demonstrated for a long time that aging is characterized by progressive decline in the efficiency of physiological functions many of which are the consequence of free radical-induced damage to cellular macromolecules. Moreover, the age-dependent inability to counterbalance these changes by endogenous antioxidant defenses can also contribute to the oxidative damage.

Mitochondria are the main source of ROS. It has been suggested that the mitochondrial rate of free radical production has a strong correlation with maximum longevity.

Many recent concepts of biology or medicine have underlined the importance of nutrition for the maintenance of "physiological" changes during aging or insults stemming from various degenerative diseases. The role of balanced nutrition in human health is now well documented in different fields such as neuroscience.

Epidemiological analysis of the relations between nutrient consumption and neurodegeneration is complex and it is highly unlikely that a single component might play a major role. In addition, since multiple factors across the human life span might influence the brain function in adulthood and in the elderly, multidomain interventions might be more promising in the prevention of the neurodegeneration.

Moreover, it has been demonstrated that caloric restriction can increase the functional and maximal lifespan in rodents and accumulating evidence demonstrates that the selection of appropriate whole foods or the addition of antioxidants into the diet is beneficial for increasing the functional lifespan, if not the maximal lifespan. One could then argue that caloric selection may be as important as caloric restriction.

However, the knowledge of the brain bioavailability of these compounds as well as their transport across blood-brain barrier remains still insufficient and inconsistent. Thus, designing such trials remains very challenging for researchers.

This special issue aims at creating a multidisciplinary forum for discussing nutritional interventions in neurodegenerative disorders associated with oxidative stress and the role of nutrients in the development of new preventive and therapeutic areas regarding neurodegenerative diseases.

The main objective of this special issue is to review data linking potential protective factors to neurodegeneration induced by oxidative stress, focusing particularly on the roles of caloric restriction, micro- and macronutrients, and the gut-brain axis. This issue accepts high quality articles containing original research results and review articles of exceptional merit.

Potential topics include but are not limited to the following:

  • Nutritional intervention in oxidative stress and neurodegenerative diseases
  • Nutritional control of the age-associated neuroinflammation
  • Nutritional status, oxidative stress, and dementia
  • Nutritional and pharmacological control of brain oxidative damage
  • Metabolic diseases and brain oxidative stress
  • The impact of the gut microbiota for brain oxidative stress

Articles

  • Special Issue
  • - Volume 2018
  • - Article ID 3416028
  • - Editorial

Oxidative Stress in Aging Brain: Nutritional and Pharmacological Interventions for Neurodegenerative Disorders

Anna Maria Giudetti | Michel Salzet | Tommaso Cassano
  • Special Issue
  • - Volume 2018
  • - Article ID 4720532
  • - Research Article

Palmitoylethanolamide Dampens Reactive Astrogliosis and Improves Neuronal Trophic Support in a Triple Transgenic Model of Alzheimer’s Disease: In Vitro and In Vivo Evidence

Maria Rosanna Bronzuoli | Roberta Facchinetti | ... | Caterina Scuderi
  • Special Issue
  • - Volume 2017
  • - Article ID 9076052
  • - Research Article

Oleic Acid and Hydroxytyrosol Inhibit Cholesterol and Fatty Acid Synthesis in C6 Glioma Cells

Paola Priore | Antonio Gnoni | ... | Fabrizio Damiano
  • Special Issue
  • - Volume 2017
  • - Article ID 8526438
  • - Review Article

Polyphenols and Oxidative Stress in Atherosclerosis-Related Ischemic Heart Disease and Stroke

Yu-Chen Cheng | Jer-Ming Sheen | ... | Yu-Chiang Hung
  • Special Issue
  • - Volume 2017
  • - Article ID 6019796
  • - Research Article

Effects of Aging and Tocotrienol-Rich Fraction Supplementation on Brain Arginine Metabolism in Rats

Musalmah Mazlan | Hamizah Shahirah Hamezah | ... | Hanafi Ahmad Damanhuri
  • Special Issue
  • - Volume 2017
  • - Article ID 7205082
  • - Research Article

Edible Bird’s Nest Prevents Menopause-Related Memory and Cognitive Decline in Rats via Increased Hippocampal Sirtuin-1 Expression

Zhiping Hou | Peiyuan He | ... | Maznah Ismail
  • Special Issue
  • - Volume 2017
  • - Article ID 2198243
  • - Research Article

Resveratrol Modulation of Protein Expression in parkin-Mutant Human Skin Fibroblasts: A Proteomic Approach

Daniele Vergara | Antonio Gaballo | ... | Michele Maffia
  • Special Issue
  • - Volume 2017
  • - Article ID 6405278
  • - Research Article

Role of Diet and Nutritional Supplements in Parkinson’s Disease Progression

Laurie K. Mischley | Richard C. Lau | Rachel D. Bennett
  • Special Issue
  • - Volume 2017
  • - Article ID 4184562
  • - Research Article

Pharmacological Basis for Use of Armillaria mellea Polysaccharides in Alzheimer’s Disease: Antiapoptosis and Antioxidation

Shengshu An | Wenqian Lu | ... | Di Wang
  • Special Issue
  • - Volume 2017
  • - Article ID 3103272
  • - Research Article

A Cystine-Rich Whey Supplement (Immunocal®) Provides Neuroprotection from Diverse Oxidative Stress-Inducing Agents In Vitro by Preserving Cellular Glutathione

Aimee N. Winter | Erika K. Ross | ... | Daniel A. Linseman
Oxidative Medicine and Cellular Longevity
 Journal metrics
Acceptance rate48%
Submission to final decision56 days
Acceptance to publication37 days
CiteScore7.300
Impact Factor5.076
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