Interstitial lung diseases (ILDs) are a large, heterogeneous group of disorders with different etiologies, clinical, radiological, and pathological presentation, natural histories, and prognosis. Overall, we can distinguish two different types of ILDs: fibrotic with idiopathic pulmonary fibrosis (IPF) as a typical representant of this group, and immunoinflammatory such as sarcoidosis.

A significant number of these diseases are idiopathic however mitochondrial abnormalities, oxidative stress, and senescence are listed among the factors that contribute to the pathobiology of this group of diseases.

The aim of this Special Issue is to collate original research articles providing evidence for the impact of mitochondrial functioning abnormalities and ultrastructural changes, oxidative stress, senescence and aging in the pathobiology, natural history, and prognosis in ILDs. We also hope that this Special Issue will solicit translational studies with clear clinical implications. Moreover, submissions discussing the potential application of agents, which target mitochondria, oxidative stress, and broad aspects of senescence, and aging are encouraged. Review articles discussing the current state of the art are also welcome.

Potential topics include but are not limited to the following:

• Idiopathic pulmonary fibrosis, and other idiopathic interstitial pneumonia
• Hypersensitivity pneumonitis
• Sarcoidosis
• Rare diffuse parenchymal lung disease
• Connective tissue disease-associated interstitial lung disease