Oxidative Medicine and Cellular Longevity

Applications of Antioxidants in Ameliorating Drugs and Xenobiotics Toxicity: Mechanistic Approach


Status
Published

1Suez Canal University, Ismailia, Egypt

2Tokyo University of Science, Chiba, Japan

3University of Texas Medical Branch, Galveston, USA

4Research Center for Food and Nutrition, Rome, Italy


Applications of Antioxidants in Ameliorating Drugs and Xenobiotics Toxicity: Mechanistic Approach

Description

Reactive oxygen species (ROS) induce degradation of cellular macromolecules such as DNA, protein, and lipid and thus lead to cellular oxidative damage. Many drugs and xenobiotics contribute to the formation of free radicals in the body, inducing oxidative stress as a mechanism of toxicity. In the laboratory, many diseases (cancer, diabetes, atherosclerosis, hypertension, Alzheimer's, and Parkinsonism) and cellular senescence as well as many inflammatory conditions developed as models by certain chemical inducers with ROS generation as a mechanism.

Natural antioxidants have a wide range of biological activities and fewer side effects. Currently, a plethora of phytochemical antioxidants could be used in healthcare to maintain normal homeostasis and for prevention and treatment of many diseases and toxicities. Targeting of the molecular mechanisms of antioxidants remains the primary focus of many investigators for better understanding of their biological activities.

This special issue is dedicated to integrate the previous and the current therapeutic and protective use of antioxidants against drugs and xenobiotics toxicity. We cordially invite researchers to contribute their original articles and reviews in our special issue.

Potential topics include but are not limited to the following:

  • Isolation, chemical characterization, and pharmacological evaluation antioxidants
  • Identification of novel phenolics and polyphenolics as therapeutic agents
  • Antioxidants against drugs and chemicals' toxicities
  • Implication of antioxidants in disease prevention
  • Prophylactic and therapeutic roles of antioxidants against different chemically induced disease models including cancer, diabetes, neurodegenerative, cardiovascular, metabolic abnormalities, and inflammatory conditions
  • Novel phytochemical antioxidants and their mechanism of actions

Articles

  • Special Issue
  • - Volume 2017
  • - Article ID 4565127
  • - Editorial

Applications of Antioxidants in Ameliorating Drugs and Xenobiotics Toxicity: Mechanistic Approach

Mohamed M. Abdel-Daim | Yasser M. Moustafa | ... | Elena Azzini
  • Special Issue
  • - Volume 2017
  • - Article ID 5604746
  • - Research Article

Genetic Transformation and Hairy Root Induction Enhance the Antioxidant Potential of Lactuca serriola L.

Mohamed A. El-Esawi | Amr Elkelish | ... | Margaret Ahmad
  • Special Issue
  • - Volume 2017
  • - Article ID 3281670
  • - Research Article

Diosmin Attenuates Methotrexate-Induced Hepatic, Renal, and Cardiac Injury: A Biochemical and Histopathological Study in Mice

Mohamed M. Abdel-Daim | Hesham A. Khalifa | ... | Saleh A. Al-Quraishy
  • Special Issue
  • - Volume 2017
  • - Article ID 5032102
  • - Review Article

Effects of Antioxidant Supplements on the Survival and Differentiation of Stem Cells

Sara Shaban | Mostafa Wanees Ahmed El-Husseny | ... | Mohamed M. Abdel-Daim
  • Special Issue
  • - Volume 2017
  • - Article ID 1351945
  • - Research Article

Modulatory Effect of Monochromatic Blue Light on Heat Stress Response in Commercial Broilers

Safaa E. Abdo | Seham El-Kassas | ... | Shawky Mahmoud
  • Special Issue
  • - Volume 2017
  • - Article ID 5985219
  • - Research Article

Camellia sinensis Prevents Perinatal Nicotine-Induced Neurobehavioral Alterations, Tissue Injury, and Oxidative Stress in Male and Female Mice Newborns

Jamaan S. Ajarem | Gadh Al-Basher | ... | Ayman M. Mahmoud
  • Special Issue
  • - Volume 2017
  • - Article ID 7528090
  • - Research Article

MitoTEMPO Prevents Oxalate Induced Injury in NRK-52E Cells via Inhibiting Mitochondrial Dysfunction and Modulating Oxidative Stress

Jiaqiao Zhang | Qing Wang | ... | Jihong Liu
  • Special Issue
  • - Volume 2016
  • - Article ID 8715185
  • - Research Article

Nephroprotective Effects of N-Acetylcysteine Amide against Contrast-Induced Nephropathy through Upregulating Thioredoxin-1, Inhibiting ASK1/p38MAPK Pathway, and Suppressing Oxidative Stress and Apoptosis in Rats

Xuezhong Gong | Yiru Duan | ... | Tom K. Hei
  • Special Issue
  • - Volume 2016
  • - Article ID 5454963
  • - Research Article

Dietary Supplementation of Phoenix dactylifera Seeds Enhances Performance, Immune Response, and Antioxidant Status in Broilers

Ali H. El-Far | Hamada A. Ahmed | Hazem M. Shaheen
Oxidative Medicine and Cellular Longevity
 Journal metrics
Acceptance rate48%
Submission to final decision56 days
Acceptance to publication37 days
CiteScore7.300
Impact Factor5.076
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