Redox imbalance is one of the most prominent symptoms in patients suffering from metabolic diseases, often caused by an active inflammatory response or excess oxidative stress. The population of people with obesity and diabetes has increased rapidly all over the world. An increasing amount of scientific data is implying that dietary bioactive compounds, such as phytochemicals and nutraceuticals, can protect cells from excess oxidative/endoplasmic reticulum stress and ameliorate related diseases via regulating cell redox signaling pathways and changing gut microbiota. Meanwhile, many molecules are considered to perform vital bio-functions in repairing metabolic disorders caused by excess oxidative/endoplasmic reticulum stress. However, the detailed mechanisms underlying the role of these bioactive compounds in the regulation of inflammation, oxidative/endoplasmic reticulum stress, and the microbiome in chronic diseases remain largely unclear.

In this Special Issue, we invite distinguished investigators to contribute original research articles using in vitro or in vivo models, coupled with multi-omics tools or clinical studies, to address the roles of phytochemicals or other dietary bioactive compounds on the regulation of cell redox signaling and oxidative/endoplasmic reticulum stress according to organ/cell type, and further elucidate or reveal the molecular mechanisms underlying their actions, especially with the aid of multi-omics. Review articles are also welcomed.

Potential topics include but are not limited to the following:

• The role of bioactive compounds in the development of oxidative/endoplasmic reticulum stress-related human diseases
• The underlying mechanisms of the modulation of intestinal epithelia, gut microbiota, and oxidative/endoplasmic reticulum stress
• The impact of dietary bioactive compounds on molecular, genetic, and biochemical biomarkers of oxidative/endoplasmic reticulum stress-related metabolic diseases
• Multi-omics tools application in revealing the relationship between phytochemicals and human diseases
• The regulation mechanism of bioactive compounds in diabetes, obesity and its complications
• Development of nutritional strategies to reduce the risks caused by dietary bioactive compounds