Oxidative Medicine and Cellular Longevity

Role of Oxidative Stress in Liver Health and Disease


Status
Published

Lead Editor
Guest Editors

1Cinvestav, Mexico, Mexico

2George Washington University, Washington, USA


Role of Oxidative Stress in Liver Health and Disease

Description

The redox status provides a balance for the optimus function of any organ, including the liver. Hepatic diseases represent a health problem with significant morbidity and mortality. Reactive oxygen and nitrogen species (ROS and RNS) are produced by metabolism of normal cells. However, in liver diseases, redox is increased, thereby damaging the hepatic tissue; the capability of ethanol to increase both ROS/RNS and peroxidation of lipids, DNA, and proteins was demonstrated in a variety of systems, cells, and species, including humans. ROS/RNS can activate hepatic stellate cells, which are characterized by the enhanced production of extracellular matrix and accelerated proliferation. Cross-talk between parenchymal and nonparenchymal cells is one of the most important events in liver injury and fibrogenesis; ROS play an important role in fibrogenesis throughout increasing platelet-derived growth factor.

Most hepatocellular carcinomas occur in cirrhotic livers, and the common mechanism for hepatocarcinogenesis is chronic inflammation associated with severe oxidative stress; other risk factors are dietary aflatoxin B(1) consumption, cigarette smoking, and heavy drinking. Ischemia-reperfusion injury affects directly hepatocyte viability, particularly during transplantation and hepatic surgery; ischemia activates Kupffer cells which are the main source of ROS during the reperfusion period. The toxic action mechanism of paracetamol is focused on metabolic activation of the drug, depletion of glutathione, and covalent binding of the reactive metabolite N-acetyl-p-benzoquinone imine to cellular proteins as the main cause of hepatic cell death; intracellular steps critical for cell death include mitochondrial dysfunction and, importantly, the formation of ROS and peroxynitrite. Infection with hepatitis C is associated with increased levels of ROS/RNS and decreased antioxidant levels. As a consequence, antioxidants have been proposed as an adjunct therapy for various liver diseases.

Potential topics include, but are not limited to:

  • Free radicals and liver damage
  • Mitochondrial dysfunction and oxidative stress
  • Flavonoids and the liver
  • Methods to evaluate oxidative stress in the liver
  • Participation of reactive oxygen and nitrogen species on fibrosis and cancer
  • Participation of oxidative stress on alcoholic and nonalcoholic liver disease
  • Herbal remedies for liver diseases

Articles

  • Special Issue
  • - Volume 2016
  • - Article ID 9037051
  • - Editorial

Role of Oxidative Stress in Liver Health and Disease

Pablo Muriel | Karina R. Gordillo
  • Special Issue
  • - Volume 2016
  • - Article ID 3928714
  • - Review Article

Ion Channels and Oxidative Stress as a Potential Link for the Diagnosis or Treatment of Liver Diseases

Ana Ramírez | Alma Yolanda Vázquez-Sánchez | ... | Javier Camacho
  • Special Issue
  • - Volume 2016
  • - Article ID 5017460
  • - Research Article

Protective Role of Dietary Curcumin in the Prevention of the Oxidative Stress Induced by Chronic Alcohol with respect to Hepatic Injury and Antiatherogenic Markers

Ravi Varatharajalu | Mamatha Garige | ... | M. Raj Lakshman
  • Special Issue
  • - Volume 2016
  • - Article ID 3196431
  • - Research Article

Spironolactone Effect in Hepatic Ischemia/Reperfusion Injury in Wistar Rats

Julio César Jiménez Pérez | Araní Casillas Ramírez | ... | Paula Cordero Pérez
  • Special Issue
  • - Volume 2016
  • - Article ID 3935841
  • - Research Article

Oligonol Ameliorates CCl4-Induced Liver Injury in Rats via the NF-Kappa B and MAPK Signaling Pathways

Jeonghyeon Bak | Nam Kyung Je | ... | Jeon-Ok Moon
  • Special Issue
  • - Volume 2016
  • - Article ID 3190617
  • - Research Article

Sympathetic Nervous System Control of Carbon Tetrachloride-Induced Oxidative Stress in Liver through α-Adrenergic Signaling

Jung-Chun Lin | Yi-Jen Peng | ... | Herng-Sheng Lee
  • Special Issue
  • - Volume 2016
  • - Article ID 3529149
  • - Review Article

Is Liver Enzyme Release Really Associated with Cell Necrosis Induced by Oxidant Stress?

Martha Lucinda Contreras-Zentella | Rolando Hernández-Muñoz
  • Special Issue
  • - Volume 2016
  • - Article ID 9209825
  • - Research Article

Cholesterol Enhances the Toxic Effect of Ethanol and Acetaldehyde in Primary Mouse Hepatocytes

Anayelly López-Islas | Victoria Chagoya-Hazas | ... | María-Concepción Gutiérrez-Ruiz
  • Special Issue
  • - Volume 2016
  • - Article ID 8327410
  • - Review Article

Oxidative Stress in the Healthy and Wounded Hepatocyte: A Cellular Organelles Perspective

Tommaso Mello | Francesca Zanieri | ... | Andrea Galli
  • Special Issue
  • - Volume 2016
  • - Article ID 1429835
  • - Research Article

The Protective Effects of Trypsin Inhibitor on Hepatic Ischemia-Reperfusion Injury and Liver Graft Survival

Lianyue Guan | Hongyu Liu | ... | Wei Li
Oxidative Medicine and Cellular Longevity
 Journal metrics
Acceptance rate48%
Submission to final decision56 days
Acceptance to publication37 days
CiteScore7.300
Impact Factor5.076
 Submit