The increase of old and new pollutants heavily conditions the quality of life. Sensitivity-related illnesses (SRIs) has brought into focus a new inhomogeneous cluster of adverse, often disabling, clinical conditions generally still lacking a complete nosologic classification. They are elicited by exposure to low doses of environmental pollutants innocuous to the general population, that is, xenobiotic, new iatrogenic factors like biocompatible implants, food, or allergens. An increasing laboratory and epidemiologic studies on the diverse environment-associated conditions, fibromyalgia, chronic fatigue and sick building/house syndromes, hypersensitivity to electromagnetic fields, and others, highlight common molecular features on a genetic or metabolic base. Altered ability to detoxify endogenous and exogenous free radical formation is accompanied by specific profiles of inflammatory cytokines, oxidative stress markers, impaired detoxifying and antioxidant capacities. Research on the SRI models may indicate new solutions in environmental toxicology and medicine, through modern protocols of genomic, epigenomic, and metabolomic diagnostics, complying with good practice criteria, validated for clinical use, with potentially larger application in environmental medicine and dermatology. In association with toxico- and pharmaco-genomics, these are bound to offer a solid rationale for evidence-based individualized therapy (antioxidant/chelator/natural immunomodulating treatments).

We invite researchers to contribute with original research or review articles that will stimulate the ongoing efforts to identify specific biomarkers of environmental hypersensitivity to be measured in the clinical setting, applicable for environmental-connected disorders, and may in perspective also provide mechanistic insights, prognostic and therapeutic indicators, and nutritional/lifestyle recommendations for chronic inflammatory conditions with suspected environmental-borne etiological cofactors (atopic or autoimmune skin pathologies, or metabolism diseases). Potential topics include, but are not limited to:

• Results of evidence-based clinical and experimental studies on multiple chemical sensitivity and related SRI
• Clinically validated biomarkers of oxidative stress and detoxification impairment in individualized environmental medicine (EM)
• Genomic and pharmacogenomic tools in EM
• Skin and environmental-borne diseases

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