Translational medicine is patient-centered, problem-oriented, and application-aimed, effectively translating basic research results into clinical use. In recent years, translational medicine has been the subject of increasing research, in particular in how it can be applied to the relationship between redox biology and the mechanisms of tumorigenesis.

Oxidative stress is an important biological feature of tumor cells. Compared with normal cells, tumor cells tend to have higher levels of reactive oxygen species (ROS) leading to oxidative stress. A certain threshold of oxidative stress can promote the occurrence and development of tumors by regulating various signaling pathways, while excessive oxidative stress can lead to oxidative damage and even the death of tumor cells. Therefore, while tumor cells have a high ROS level, they also activate the intracellular antioxidant system to relieve oxidative stress, maintaining intracellular redox homeostasis and promoting tumor cell survival. However, there are several obstacles facing translational research in redox and tumor biology, such as tumor heterogeneity, drug resistance, pathogenesis, and metastasis, which are all in urgent need of further elucidation. Translational medicine will help progress cutting-edge trends in tumor research and translate highly promising basic research into clinical experimentation and use.

The aim of this Special Issue is to collection translational research focusing on the redox biology involved in tumor mechanisms, with the aim of improving current diagnosis and prognosis and treatment strategies. High quality original studies that describe different aspects of translational tumor research on redox biology in the diagnosis and treatment of tumors are welcome, as are review articles.

Potential topics include but are not limited to the following:

• In vitro and in vivo translational research on the role of redox biology in the diagnosis and treatment of tumors
• Molecular mechanisms of the relationship between oxidative stress and tumorigenesis processes, including tumor heterogeneity, pathogenesis, and metastasis
• Biomarkers regulating oxidative stress in the diagnosis and prognosis of tumors
• Novel therapeutic strategies targeting oxidative stress
• Molecular mechanisms and signaling pathways in oxidative stress and tumor drug resistance
• Synthesis, characterization, and delivery efficacy of biomaterials related to oxidative stress in the diagnosis and prognosis of tumors
• Omics and multi-omics profiling of tissues and physiological fluids relating to redox biology in the diagnosis and treatment of tumor