Oxidative Medicine and Cellular Longevity

Oxidative Stress: Neuropathy, Excitability, and Neurodegeneration


Status
Published

1Université de Montréal, Montreal, Canada

2Federal University of Santa Catarina, Florianópolis, Brazil

3Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil


Oxidative Stress: Neuropathy, Excitability, and Neurodegeneration

Description

Energy production by aerobic cellular metabolism generates free radicals. Imbalance between the production of these radicals and their elimination via antioxidant defenses lead to oxidative stress. The toxicity of free radicals contributes to proteins and DNA injury, inflammation, tissue damage, and subsequent cellular apoptosis. Due to their very high demands in energy, large numbers of mitochondria, reduced capability of limiting glucose uptake, weak antioxidant defense, and weak bioavailability to antioxidant treatment and molecules, neurons are highly susceptible to reactive oxygen species- (ROS-) mediated damage. Alongside environmental and/or genetic factors, oxidative stress (OS) leads to a range of disorders such as Amyotrophic Lateral Sclerosis, Alzheimer's disease, and Parkinson's disease as well as chemotherapy- and diabetic-induced neuropathy. Thus, reduced antioxidant defense, overproduction, or incorporation of free radicals from the environment into the system leads to neurodegeneration. For example, diabetes-induced hyperglycemia enhanced neuronal ROS levels, leading to damaged proteins, decreased biological activity, reduced energy, impaired signaling, and protein trafficking which ultimately lead to neuronal death characteristic of diabetic neuropathy.

We invite investigators to contribute to this special issue with original research articles as well as reviews addressing the physiology, the mechanisms, and the impact of oxidative stress in neuron excitability, neurodegeneration, and neuropathy. The potential of antioxidant therapy or alternative ways to recess or control free radicals generation is also of interest. While this topic has been extensively studied, recent advances linking excitability, oxidative stress, and degeneration emerged, and such cascade appears as a major driver in CNS pathology. A particular attention will therefore be given on manuscript exploring or discussing the mechanism of neuronal excitability and oxidative stress.

Potential topics include but are not limited to the following:

  • Mechanism leading to oxidative stress; physiology; and pathology
    • Mitochondrial dysfunction
    • Hyperglycemia
    • ER-stress
    • Chemotherapy
    • Nerve injury
  • Consequences of increased oxidative stress on neuron function
    • Diabetes-related neurological implications
    • Hyperexcitability
    • Small fiber Neuropathy
    • Neurodegeneration
  • Potential treatment
    • Antioxidant

Articles

  • Special Issue
  • - Volume 2019
  • - Article ID 2715326
  • - Editorial

Oxidative Stress: Neuropathy, Excitability, and Neurodegeneration

Alexandra Latini | Paula Juliana Seadi Pereira | ... | Sébastien Talbot
  • Special Issue
  • - Volume 2018
  • - Article ID 4070935
  • - Research Article

Effects of Long-Term Treatment with a Blend of Highly Purified Olive Secoiridoids on Cognition and Brain ATP Levels in Aged NMRI Mice

Martina Reutzel | Rekha Grewal | ... | Gunter P. Eckert
  • Special Issue
  • - Volume 2018
  • - Article ID 6736721
  • - Research Article

Protective Role of UCP2 in Oxidative Stress and Apoptosis during the Silent Phase of an Experimental Model of Epilepsy Induced by Pilocarpine

Marina Rascio Henriques Dutra | Regiane dos Santos Feliciano | ... | José Antônio Silva
  • Special Issue
  • - Volume 2018
  • - Article ID 3760124
  • - Research Article

Isolation and Characterization of NP-POL Nonapeptide for Possible Therapeutic Use in Parkinson’s Disease

Marta Lemieszewska | Antoni Polanowski | ... | Agnieszka Zabłocka
  • Special Issue
  • - Volume 2018
  • - Article ID 5272741
  • - Review Article

Relevance of Alternative Routes of Kynurenic Acid Production in the Brain

L. A. Ramos-Chávez | R. Lugo Huitrón | ... | V. Pérez de la Cruz
  • Special Issue
  • - Volume 2018
  • - Article ID 1873962
  • - Review Article

Antioxidant and Cell-Signaling Functions of Hydrogen Sulfide in the Central Nervous System

Ulfuara Shefa | Min-Sik Kim | ... | Junyang Jung
  • Special Issue
  • - Volume 2017
  • - Article ID 5049532
  • - Review Article

Omega Class Glutathione S-Transferase: Antioxidant Enzyme in Pathogenesis of Neurodegenerative Diseases

Youngjo Kim | Sun Joo Cha | ... | Kiyoung Kim
  • Special Issue
  • - Volume 2017
  • - Article ID 3940241
  • - Review Article

Ischemic Retinopathies: Oxidative Stress and Inflammation

José Carlos Rivera | Rabah Dabouz | ... | Sylvain Chemtob
Oxidative Medicine and Cellular Longevity
 Journal metrics
Acceptance rate43%
Submission to final decision54 days
Acceptance to publication39 days
CiteScore7.300
Impact Factor5.076
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