Oxidative Medicine and Cellular Longevity

Role of Oxidative, Nitrative, and Chlorinative Protein Modifications in Aging and Age-Related Diseases


Status
Published

1University of Rzeszów, Rzeszów, Poland

2University of Łódź, Łódź, Poland

3German Institute of Human Nutrition, Nuthetal, Germany

4Vilnius Gediminas Technical University, Vilnius, Lithuania


Role of Oxidative, Nitrative, and Chlorinative Protein Modifications in Aging and Age-Related Diseases

Description

Oxidative stress accompanies many age-related diseases and contributes to the development of many of them; especially type 2 diabetes mellitus, atherosclerosis, cataract, and neurodegenerative diseases. Sequelae of oxidative stress include oxidative protein modifications. Reactive oxygen species can lead to oxidation of amino acid side chains (oxidation of thiols to different forms, oxidation of methionine, formation of carbonyl groups, etc.), modification by products of glycoxidation and lipoxidation, and formation of protein-protein cross-links as well as oxidation of the protein backbone resulting in protein fragmentation.

Aging is also associated with oxidative stress and accumulation of oxidatively modified proteins, such as inactive or less active, more heat-labile forms of numerous enzymes. However, new data are still needed to understand the role of oxidatively modified proteins in aging and age-related diseases, mechanisms of their modifications and accumulation, and novel methods of their detection. An intriguing question is whether oxidatively modified proteins may be disease markers. We invite authors to submit original research and review articles in this field.

Potential topics include but are not limited to the following:

  • New data on the occurrence of oxidatively modified proteins in age-related diseases
  • New data on the accumulation of oxidatively modified proteins in aging of man and in model organisms
  • New methods for detection of oxidatively modified proteins
  • Oxidatively modified proteins as markers of age-related diseases

Articles

  • Special Issue
  • - Volume 2018
  • - Article ID 3267898
  • - Editorial

Role of Oxidative, Nitrative, and Chlorinative Protein Modifications in Aging and Age-Related Diseases

Izabela Sadowska-Bartosz | Grzegorz Bartosz | ... | Jolanta Sereikaite
  • Special Issue
  • - Volume 2018
  • - Article ID 8520746
  • - Research Article

High Cholesterol Diet-Induced Changes in Oxysterol and Scavenger Receptor Levels in Heart Tissue

Erdi Sozen | Burak Yazgan | ... | Nesrin Kartal Ozer
  • Special Issue
  • - Volume 2018
  • - Article ID 2737563
  • - Research Article

Work Intensity, Low-Grade Inflammation, and Oxidative Status: A Comparison between Office and Slaughterhouse Workers

Sieglinde Zelzer | Franz Tatzber | ... | Harald Mangge
  • Special Issue
  • - Volume 2017
  • - Article ID 9692546
  • - Research Article

Activation of NLRP3 Inflammasome by Advanced Glycation End Products Promotes Pancreatic Islet Damage

Xiang Kong | Ai-Ling Lu | ... | Qing Su
  • Special Issue
  • - Volume 2017
  • - Article ID 7905148
  • - Research Article

Oxidative Modification of Blood Serum Proteins in Multiple Sclerosis after Interferon Beta and Melatonin Treatment

Monika Adamczyk-Sowa | Sabina Galiniak | ... | Izabela Sadowska-Bartosz
  • Special Issue
  • - Volume 2017
  • - Article ID 1910450
  • - Research Article

Ghrelin Protects Human Lens Epithelial Cells against Oxidative Stress-Induced Damage

Jie Bai | Fan Yang | ... | Yi Zheng
  • Special Issue
  • - Volume 2017
  • - Article ID 5716409
  • - Review Article

Protein Posttranslational Modifications: Roles in Aging and Age-Related Disease

Ana L. Santos | Ariel B. Lindner
  • Special Issue
  • - Volume 2017
  • - Article ID 1401452
  • - Research Article

Associations between Specific Redox Biomarkers and Age in a Large European Cohort: The MARK-AGE Project

Daniela Weber | Wolfgang Stuetz | ... | Tilman Grune
Oxidative Medicine and Cellular Longevity
 Journal metrics
Acceptance rate48%
Submission to final decision56 days
Acceptance to publication37 days
CiteScore7.300
Impact Factor5.076
 Submit