Role of Oxidative, Nitrative, and Chlorinative Protein Modifications in Aging and Age-Related Diseases
1University of Rzeszów, Rzeszów, Poland
2University of Łódź, Łódź, Poland
3German Institute of Human Nutrition, Nuthetal, Germany
4Vilnius Gediminas Technical University, Vilnius, Lithuania
Role of Oxidative, Nitrative, and Chlorinative Protein Modifications in Aging and Age-Related Diseases
Description
Oxidative stress accompanies many age-related diseases and contributes to the development of many of them; especially type 2 diabetes mellitus, atherosclerosis, cataract, and neurodegenerative diseases. Sequelae of oxidative stress include oxidative protein modifications. Reactive oxygen species can lead to oxidation of amino acid side chains (oxidation of thiols to different forms, oxidation of methionine, formation of carbonyl groups, etc.), modification by products of glycoxidation and lipoxidation, and formation of protein-protein cross-links as well as oxidation of the protein backbone resulting in protein fragmentation.
Aging is also associated with oxidative stress and accumulation of oxidatively modified proteins, such as inactive or less active, more heat-labile forms of numerous enzymes. However, new data are still needed to understand the role of oxidatively modified proteins in aging and age-related diseases, mechanisms of their modifications and accumulation, and novel methods of their detection. An intriguing question is whether oxidatively modified proteins may be disease markers. We invite authors to submit original research and review articles in this field.
Potential topics include but are not limited to the following:
- New data on the occurrence of oxidatively modified proteins in age-related diseases
- New data on the accumulation of oxidatively modified proteins in aging of man and in model organisms
- New methods for detection of oxidatively modified proteins
- Oxidatively modified proteins as markers of age-related diseases