Oxidative Medicine and Cellular Longevity

Redox Signaling and Myocardial Cell Death: Molecular Mechanisms and Drug Targets


Status
Published

Lead Editor

1UAE University, Al-Ain, UAE

2University of Louisville, Louisville, USA

3National Institutes of Health, Bethesda, USA

4SASTRA University, Tamil Nadu, India


Redox Signaling and Myocardial Cell Death: Molecular Mechanisms and Drug Targets

Description

Apoptotic cardiac cell demise has been demonstrated in myocardial tissues obtained from patients with congestive heart failure, acute myocardial infraction, arrhythmogenic right ventricular dysplasia, myocarditis, chemotherapy induced cardiomyopathies, diabetic cardiomyopathy, and so forth. Further, loss of functional capacity of the myocytes from apoptotic injury accounts for the major cause of morbidity and mortality in the above-mentioned heart diseases. Thus prevention of cardiomyocyte cell death (preserving functional myocardium) could have profound clinical implications in the treatment of acute myocardial infraction, heart failure, and so forth.

However, the development of specific inhibitors of cardiomyocyte apoptosis is currently restricted by our limited understanding of the signaling process involved in this process. In addition, the individual factors, that trigger and mediate the apoptotic cell death in the myocardium, are also murky. In light of these challenges, we invite investigators to contribute their critical review articles and original contributions that will stimulate our continuing efforts to understand the molecular and cellular pathophysiological mechanisms and impairments that culminate in the cardiomyocyte demise.

Potential topics include, but are not limited to:

  • Oxidative stress induced redox-signaling and apoptosis in the myocardium
  • Molecular triggers, mediators, and regulators of apoptotic cell death in the myocardium
  • Role of mitochondria derived reactive oxygen free radicals in the myocardial cell death
  • Advances in the development and utility of novel in vitro and preclinical experimental models to investigate and understand the pathophysiology of apoptotic myocardial cell death
  • Biomarkers for cardiomyocyte cell death and prototype developments (small molecule inhibitors) to mitigate cardiomyocyte apoptosis
  • Other modes of treatment approaches such as cell based therapies (stem cells) and use of plant derived chemicals (phytochemicals) to repair the injured myocardium and prevent the myocardial cell death

Articles

  • Special Issue
  • - Volume 2016
  • - Article ID 3190753
  • - Editorial

Redox Signaling and Myocardial Cell Death: Molecular Mechanisms and Drug Targets

Mohanraj Rajesh | Lu Cai | ... | Srinivasan Vedantham
  • Special Issue
  • - Volume 2016
  • - Article ID 4298945
  • - Research Article

Exogenous Nitric Oxide Protects Human Embryonic Stem Cell-Derived Cardiomyocytes against Ischemia/Reperfusion Injury

János Pálóczi | Zoltán V. Varga | ... | Anikó Görbe
  • Special Issue
  • - Volume 2016
  • - Article ID 1656450
  • - Review Article

The Role of Oxidative Stress in Myocardial Ischemia and Reperfusion Injury and Remodeling: Revisited

Gino A. Kurian | Rashmi Rajagopal | ... | Mohanraj Rajesh
  • Special Issue
  • - Volume 2016
  • - Article ID 5724973
  • - Review Article

Cardioprotective Potentials of Plant-Derived Small Molecules against Doxorubicin Associated Cardiotoxicity

Shreesh Ojha | Hasan Al Taee | ... | Mohanraj Rajesh
  • Special Issue
  • - Volume 2016
  • - Article ID 8254942
  • - Review Article

The Role of Mitochondrial Reactive Oxygen Species in Cardiovascular Injury and Protective Strategies

Danina M. Muntean | Adrian Sturza | ... | Cristian Mornoș
  • Special Issue
  • - Volume 2016
  • - Article ID 5380319
  • - Research Article

Role of TFEB Mediated Autophagy, Oxidative Stress, Inflammation, and Cell Death in Endotoxin Induced Myocardial Toxicity of Young and Aged Mice

Fang Li | Fangfang Lang | ... | Enkui Hao
  • Special Issue
  • - Volume 2016
  • - Article ID 1379162
  • - Research Article

Neuroprotective Effects of Isosteviol Sodium Injection on Acute Focal Cerebral Ischemia in Rats

Hui Hu | Xiao ou Sun | ... | Wen Tan
  • Special Issue
  • - Volume 2016
  • - Article ID 6362812
  • - Research Article

Isosteviol Sensitizes sarcKATP Channels towards Pinacidil and Potentiates Mitochondrial Uncoupling of Diazoxide in Guinea Pig Ventricular Myocytes

Zhuo Fan | Ting Wen | ... | Wen Tan
  • Special Issue
  • - Volume 2016
  • - Article ID 5638943
  • - Research Article

Notch1 Pathway Protects against Burn-Induced Myocardial Injury by Repressing Reactive Oxygen Species Production through JAK2/STAT3 Signaling

Weixia Cai | Xuekang Yang | ... | Dahai Hu
Oxidative Medicine and Cellular Longevity
 Journal metrics
Acceptance rate48%
Submission to final decision56 days
Acceptance to publication37 days
CiteScore7.300
Impact Factor5.076
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