Oxidative Medicine and Cellular Longevity

Polyphenols, Oxidative Stress, and Metabolic Syndrome

Publishing date
01 Jul 2019
Submission deadline
01 Mar 2019

Lead Editor

1Huazhong University of Science and Technology, Wuhan, China

2Texas Tech University, Texas, USA

3Binzhou medical University, Shandong, China

4Xinxiang Medical University, Henan, China

5University of Texas MD Anderson Cancer Center, Texas, USA

Polyphenols, Oxidative Stress, and Metabolic Syndrome


With an increased lifespan of humans due to medical developments, chronic diseases have become a major health threat in today's world. Metabolic syndrome (MetS), referring to a series of metabolic abnormalities, including central obesity, hyperglycemia, dyslipidemia, and hypertension, is a common source for many kinds of chronic diseases like diabetes and cardiovascular diseases.

Phytochemicals are secondary metabolites of plants; they have brought a lot of inspiration to human medicine in the past, including the discovery of important drugs such as aspirin, paclitaxel, and artemisinin. Oxidative stress, which is commonly associated with obesity and MetS, has been proven to contribute to diabetes, atherogenesis, hypertension, and other cardiovascular diseases. Increasing evidence has shown that polyphenols, a group of antioxidative phytochemicals, could protect cells against oxidative damage and, therefore, reduce the risk of associated diseases. Thus, polyphenols might be a promising compound in our fighting against the pandemic of MetS and the health threat from related chronic diseases. However, despite extensive studies, the antioxidative mechanisms of polyphenols, which are far more complex beyond simple scavenging of free radicals, are still to be determined. Additionally, polyphenols also exhibit prooxidative features under certain conditions, which adds complexity to the understanding of the issue. Meanwhile, validated in vivo biomarkers of polyphenols, which could be indicators of polyphenol intake, are still lacking, and dose-response of polyphenols in MetS is still not well studied.

This special issue aims to better understand how polyphenols protect against metabolic syndromes and disorders by calling for the most advanced research in the field of polyphenols and MetS. Review articles that describe the current state or recent developments are highly encouraged.

Potential topics include but are not limited to the following:

  • The effect of specific polyphenols on MetS or related diseases
  • The role of antioxidative capacity of polyphenols on the protective effect against MetS or related diseases
  • Mechanisms underlying the antioxidative effects of polyphenols
  • Dose-response effect of polyphenols in MetS and related diseases
  • The absorption, metabolism, bioavailability and antioxidative capacity of polyphenols
  • Toxicological studies of polyphenols, oxidative stress and MetS


  • Special Issue
  • - Volume 2020
  • - Article ID 7398453
  • - Editorial

Polyphenols, Oxidative Stress, and Metabolic Syndrome

Chong Tian | Lei Hao | ... | Fangyi Xu
  • Special Issue
  • - Volume 2019
  • - Article ID 7591840
  • - Research Article

Resveratrol Attenuates Oxidative Stress-Induced Intestinal Barrier Injury through PI3K/Akt-Mediated Nrf2 Signaling Pathway

Yu Zhuang | Huirong Wu | ... | Yulong Yin
  • Special Issue
  • - Volume 2019
  • - Article ID 6713194
  • - Review Article

The Bioprotective Effects of Polyphenols on Metabolic Syndrome against Oxidative Stress: Evidences and Perspectives

Kui Liu | Miao Luo | Shuang Wei
  • Special Issue
  • - Volume 2019
  • - Article ID 5847040
  • - Research Article

Role of Resveratrol on Indoxyl Sulfate-Induced Endothelial Hyperpermeability via Aryl Hydrocarbon Receptor (AHR)/Src-Dependent Pathway

Eskedar Getachew Assefa | Qiaoqiao Yan | ... | Chenjiang Ying
  • Special Issue
  • - Volume 2019
  • - Article ID 4683723
  • - Clinical Study

A Hazelnut-Enriched Diet Modulates Oxidative Stress and Inflammation Gene Expression without Weight Gain

Laura Di Renzo | Giorgia Cioccoloni | ... | Santo Gratteri
  • Special Issue
  • - Volume 2019
  • - Article ID 4809836
  • - Research Article

Application of Urinary Polyphenol Biomarkers Measured by Liquid Chromatography Tandem Mass Spectrometry to Assess Polyphenol Intake and Their Association with Overweight and Obesity in Free-Living Healthy Subjects

Ruiyue Yang | Helu Xiu | ... | Jun Dong
Oxidative Medicine and Cellular Longevity
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