The developing brain is extremely sensitive to many chemicals. Exposure to neurotoxicants during development has been implicated in various neurodevelopmental, neuropsychiatric, and neurodegenerative disorders, including autism spectrum disorder, schizophrenia, and Parkinson’s disease.

Oxidative stress is one of the key mechanisms in the developmental neurotoxicity (DNT) of chemicals. When the balance between pro- and antioxidative signaling is compromised, the oxidative stress causes deleterious changes to brain development through the dysregulation of functional networks leading to neurodevelopmental, neuropsychiatric, and neuropsychiatric disorders. Given the growing number of chemicals used in our daily life and the socioeconomic burden of these disorders, the understanding and assessment of oxidative stress in the DNT of chemicals are needed urgently. During recent decades, our knowledge about the oxidative stress in DNT has grown considerably.

The aim of this Special Issue is to collate original research and review articles that will stimulate the understanding of oxidative stress in DNT with the hope to realize the assessment of the DNT in chemicals quickly and accurately so that they can be used safely.

Potential topics include but are not limited to the following:

• The basic molecular and cellular mechanisms underlying oxidative stress in DNT
• System-level analysis of oxidative stress in DNT
• Oxidative stress as a key event in adverse outcome pathways of DNT
• New in silico, in vitro, and in vivo models to test our understanding of oxidative stress in DNT
• Species differences in oxidative stress in DNT
• Diseases related to oxidative stress in DNT
• Protection against oxidative stress in DNT