Oxidative Medicine and Cellular Longevity

Mitochondrial Quality Control Mechanisms as Molecular Targets in Cardiovascular Disorders


Publishing date
01 Apr 2021
Status
Published
Submission deadline
04 Dec 2020

Lead Editor
Guest Editors

1Chinese PLA General Hospital, Beijing, China

2University of Minnesota, Duluth, USA

3Hebei University, Hebei, China


Mitochondrial Quality Control Mechanisms as Molecular Targets in Cardiovascular Disorders

Description

Mitochondrial quality control (MQC) is an adaptive response that adjusts the morphology and function of mitochondria during cardiovascular disorders. After exposure to stress, cardiomyocytes employ antioxidative factors to neutralize mitochondrial ROS, reduce oxidative stress damage, and ensure mitochondrial homeostasis. Concurrently, mitochondrial fission is activated so that damaged mitochondrial fractions can be removed from the mitochondrial network, with the cooperation of mitophagy. In contrast, healthy, long mitochondria can integrate with several small mitochondrial fragments to enhance the resistance of the entire mitochondrial population to stress. When these adaptive responses fail, programmed cell death by apoptosis or necroptosis is activated, and damaged mitochondria become the inducers of cell death, enabling the sequestration of incurable and dysfunctional cardiomyocytes.

During this process, mitochondrial fission and mitophagy serve as a double-edged sword in the damaged heart: on the one hand, they exert prosurvival mechanisms by isolating damaged mitochondria, and on the other hand, if fission and mitophagy persist beyond a certain threshold, they may lead to cellular demise. Therefore, selective, effective, moderate, and differential activation of mitophagy and mitigation of fission are essential for MQC and could synergistically sustain cardiac function. Necroptosis and apoptosis, although activated by various stimuli, are functionally governed solely by mitochondria. As the final steps of MQC to maintain tissue homeostasis, necroptosis and apoptosis communicate with each other and offer new targets for therapeutic approaches. Therefore, defects in MQC may determine the fate of cardiomyocytes.

The aim of this Special Issue is to collate original research and review articles that discuss the regulatory mechanisms and pathological effects of MQC in cardiovascular diseases, highlighting potential targets for the clinical management of acute and chronic myocardial injuries.

Potential topics include but are not limited to the following:

  • New insights into the mechanisms underlying dysregulated mitochondrial quality control in the pathogenesis of myocardial and microvascular injuries
  • The roles of oxidative stress, mitochondrial fission, mitochondrial fusion, mitochondrial biogenesis, mitophagy, mitochondria-induced death, and mitochondrial unfolded protein response in cardiovascular disorders
  • Mitochondria-targeted approaches (such as melatonin or mitochondria-derived peptides) to attenuate the vulnerability of cardiomyocytes and endothelial cells to stressful conditions including oxidative stress, hypoxia, inflammation, ischemia-reperfusion injury, hyperglycemia, and lipotoxicity
  • Clinically relevant information on the effects of therapies for myocardium and microvessels with a focus on mitochondria
  • Novel approaches to modulate mitochondrial integrity and thus improve cardiovascular function during stressful conditions

Articles

  • Special Issue
  • - Volume 2023
  • - Article ID 9828520
  • - Retraction

Retracted: Natural Antioxidants Improve the Vulnerability of Cardiomyocytes and Vascular Endothelial Cells under Stress Conditions: A Focus on Mitochondrial Quality Control

Oxidative Medicine and Cellular Longevity
  • Special Issue
  • - Volume 2023
  • - Article ID 9815047
  • - Retraction

Retracted: Alleviation of Inflammation and Oxidative Stress in Pressure Overload-Induced Cardiac Remodeling and Heart Failure via IL-6/STAT3 Inhibition by Raloxifene

Oxidative Medicine and Cellular Longevity
  • Special Issue
  • - Volume 2023
  • - Article ID 9826087
  • - Retraction

Retracted: Total Glucosides of Peony Protect Cardiomyocytes against Oxidative Stress and Inflammation by Reversing Mitochondrial Dynamics and Bioenergetics

Oxidative Medicine and Cellular Longevity
  • Special Issue
  • - Volume 2023
  • - Article ID 9821720
  • - Retraction

Retracted: The Role of Posttranslational Modification and Mitochondrial Quality Control in Cardiovascular Diseases

Oxidative Medicine and Cellular Longevity
  • Special Issue
  • - Volume 2023
  • - Article ID 9767123
  • - Retraction

Retracted: Puerarin Attenuates LPS-Induced Inflammatory Responses and Oxidative Stress Injury in Human Umbilical Vein Endothelial Cells through Mitochondrial Quality Control

Oxidative Medicine and Cellular Longevity
  • Special Issue
  • - Volume 2023
  • - Article ID 9763019
  • - Retraction

Retracted: Oxidized LDL Disrupts Metabolism and Inhibits Macrophage Survival by Activating a miR-9/Drp1/Mitochondrial Fission Signaling Pathway

Oxidative Medicine and Cellular Longevity
  • Special Issue
  • - Volume 2023
  • - Article ID 9781259
  • - Retraction

Retracted: S-Nitroso-L-Cysteine Ameliorated Pulmonary Hypertension in the MCT-Induced Rats through Anti-ROS and Anti-Inflammatory Pathways

Oxidative Medicine and Cellular Longevity
  • Special Issue
  • - Volume 2023
  • - Article ID 9875698
  • - Retraction

Retracted: Novel Insights into the Molecular Features and Regulatory Mechanisms of Mitochondrial Dynamic Disorder in the Pathogenesis of Cardiovascular Disease

Oxidative Medicine and Cellular Longevity
  • Special Issue
  • - Volume 2023
  • - Article ID 9864208
  • - Retraction

Retracted: Modulation of Mitochondrial Quality Control Processes by BGP-15 in Oxidative Stress Scenarios: From Cell Culture to Heart Failure

Oxidative Medicine and Cellular Longevity
  • Special Issue
  • - Volume 2023
  • - Article ID 9767518
  • - Retraction

Retracted: Epicardial Adipose Tissue Volume Is Associated with High Risk Plaque Profiles in Suspect CAD Patients

Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity
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Submission to final decision133 days
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CiteScore10.100
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