Oxidative Medicine and Cellular Longevity

Redox Regulation of Cancer Epigenetics


Publishing date
01 Jan 2022
Status
Closed
Submission deadline
20 Aug 2021

Lead Editor

1Indiana University, Indianapolis, USA

2The Ohio State University, Columbus, USA

3KTH-Royal Institute of Technology, Stockholm, Sweden

This issue is now closed for submissions.
More articles will be published in the near future.

Redox Regulation of Cancer Epigenetics

This issue is now closed for submissions.
More articles will be published in the near future.

Description

Chromatin structure defines the state in which genetic information, in the form of DNA, is organized within a cell. This organization of the genome dictates the abilities of genes to be activated or silenced. Though each cell of a multicellular organism harbours the same genome (barring some of the adaptive immune cells and germline cells due to chromosomal recombination), epigenetic mechanisms are primarily responsible for the development and maintenance of tissue specific expression patterns. Recent reports and studies on cancer epigenetics have shown extensive reprogramming of every component of the epigenetic machinery in cancer, including DNA methylation, histone modification, and nucleosome positioning. These genetic and epigenetic alterations interact at all stages of cancer development, working together to promote cancer progression.

Rapidly growing tumour cells provide a microenvironment rich in reactive oxygen and nitrogen species (ROS and RNS). ROS and RNS are capable of bringing modification at a nucleotide level by conversion of 5-methylcytosine (5-mC) to 5-hydroxymethylcytosine (5-hmC). This oxidative environment also promotes DNA strand breaks, as DNA modification is further amplified under oxidative stress as DNA repair machinery is compromised due to inhibition of DNA repair enzymes. Mitochondrial manganese superoxide dismutase (MnSOD or SOD2) is reported to be repressed in certain types of tumours, such as breast cancer. SOD2 deficiency results in a significant decrease in global histone epigenetic marks such as 2meH3K4, 3meH3K9, 2meH3K27, 3meH3K27 and AcH3K9. Certain classes of histone deacetylases (HDACs) like sirtuins are also redox regulated.

The aim of this Special Issue, in light of these findings, is to invite authors to contribute original research articles, as well as review articles, exploring the role of redox regulated epigenetics landscape in cancer.

Potential topics include but are not limited to the following:

  • Reactive oxygen species (ROS) mediated genomic and epigenomic instability
  • Redox signalling as a driving force for epigenetic modifications
  • Redox responsive RNAi for cancer therapy
  • Modulation of mitochondrial bioenergetics post epigenetic changes in cancer
  • The Warburg effect as a source to generate redox equivalents in tumour micro-environment
  • Metabolic signalling of epigenetic changes in cancer
  • Redox mediated metal sensitivity in cancer
  • Redox modulation of TET enzymes in cancer
  • Modulation of oncogenic microRNAs (onco-miRs) by redox signalling in cancer

Articles

  • Special Issue
  • - Volume 2021
  • - Article ID 2088345
  • - Research Article

Methylation of CALCA and CALCB in Pancreatic Ductal Adenocarcinoma

Feng Gao | Guozhong Liu | ... | Qicai Liu
  • Special Issue
  • - Volume 2021
  • - Article ID 9959807
  • - Research Article

Exosomal lncRNA PVT1/VEGFA Axis Promotes Colon Cancer Metastasis and Stemness by Downregulation of Tumor Suppressor miR-152-3p

Shiue-Wei Lai | Ming-Yao Chen | ... | Yih-Giun Cherng
  • Special Issue
  • - Volume 2021
  • - Article ID 5522054
  • - Review Article

Role of RONS and eIFs in Cancer Progression

Yasmeen Ahmed Salaheldin | Salma Sayed Mohamed Mahmoud | ... | Xin-Ying Ji
  • Special Issue
  • - Volume 2021
  • - Article ID 6648093
  • - Research Article

Integrated Analysis to Identify a Redox-Related Prognostic Signature for Clear Cell Renal Cell Carcinoma

Yue Wu | Xian Wei | ... | Tao Wang
  • Special Issue
  • - Volume 2021
  • - Article ID 5554932
  • - Research Article

Exploring the Role and Mechanism of pAMPKα-Mediated Dysregulation of Brf1 and RNA Pol III Genes

Teng Wu | Dongkun Zhang | ... | Shuping Zhong
  • Special Issue
  • - Volume 2021
  • - Article ID 5517777
  • - Review Article

Advances in Understanding Mitochondrial MicroRNAs (mitomiRs) on the Pathogenesis of Triple-Negative Breast Cancer (TNBC)

Hung-Yu Lin | Pei-Yi Chu
  • Special Issue
  • - Volume 2021
  • - Article ID 6633867
  • - Research Article

HIF-1 Inhibitor YC-1 Reverses the Acquired Resistance of EGFR-Mutant HCC827 Cell Line with MET Amplification to Gefitinib

Qian Jin | Jisheng Zheng | ... | Feihua Huang
Oxidative Medicine and Cellular Longevity
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