Oxidative Medicine and Cellular Longevity

Antioxidant, Anti-Inflammatory, and Microbial-Modulating Activities of Nutraceuticals and Functional Foods


Publishing date
10 Feb 2017
Status
Published
Submission deadline
23 Sep 2016

Lead Editor

1Council for Agricultural Research and Economics (CREA-NUT), Rome, Italy

2University of Bari, Bari, Italy

3Universidad Católica San Antonio de Murcia (UCAM), Murcia, Spain

4Tufts University, Medford, USA

5Sapienza University of Rome, Rome, Italy


Antioxidant, Anti-Inflammatory, and Microbial-Modulating Activities of Nutraceuticals and Functional Foods

Description

Oxidative stress is defined as the imbalance between reactive oxygen species (ROS) formation and enzymatic and nonenzymatic antioxidant defense favoring the former. Enhanced oxidative stress occurs when ROS formation is increased by an array of exogenous and endogenous factors, for example, smoking, exposure to pollution, unhealthy diet, and chronic/low grade inflammation, when the antioxidant defense capacity is compromised or both. Enhanced oxidative stress has been appreciated for the contribution to the pathogenesis of noncommunicable diseases (i.e. cardiovascular disease, metabolic syndrome, cancer, and brain disorders). In addition to attacking susceptible macromolecules, protein, DNA, and lipid, ROS modulate the expression of genes that are regulated by nuclear factor-erythroid 2-related factor 2 (Nrf2) and nuclear factor-kappa B (NF-κB). For example, Nrf2 stimulates the transcription of antioxidant enzymes through the antioxidant responsive elements (ARE) and the activation of NF-κB elicits the gene expression of inflammatory cytokines. Therefore, there is a concerted modulation of Nrf2 and NF-κB in inflammation and oxidative stress. In this context, many nutraceuticals exert their anti-inflammatory and antioxidant effects through the inhibition of NF-κB and the activation of Nrf2, respectively.

Further, one of the most promising areas for the development of functional foods lies in modulation of the immune system by the use of probiotics, prebiotics, and synbiotics. Particularly, research examining the interactions occurring between probiotics, prebiotics, and nutraceuticals at the levels of the gut microbiota and of the Gut Associated Lymphoid Tissue (GALT) is emerging. These interactions are relevant in the design of nutraceuticals and functional food for the prevention of noncommunicable diseases associated with dysbiosis, oxidative stress, and chronic low-grade inflammation.

To this special issue, we invite investigators to contribute original research articles based on both preclinical and clinical data, comprehensive reviews, and perspective articles aiming to evaluate the antioxidant and anti-inflammatory activities of nutraceuticals and functional foods, as well as the functional quality assessment of both natural and industrially processed foods.

Potential topics include, but are not limited to:

  • Human, animal, or in vitro studies in relation to oxidative stress and inflammation: the effects of nutraceuticals, natural, and industrially processed foods, probiotics, prebiotics, and synbiotics
  • Molecular mechanisms of antioxidant and anti-inflammatory effects of nutraceuticals
  • Recent insights into the relationship between probiotics, prebiotics, and nutraceuticals in the area of molecular and cellular mechanisms, genetic mechanisms, and nutrition and immune modulation
  • Human, animal, or in vitro studies evaluating the effects of food, functional foods, and nutraceuticals on the host-microbiota (microbiome) interactions
  • In vivo effects of food, functional foods, and nutraceuticals on the markers of oxidative stress and inflammation
  • Characterization of novel functional foods, natural products, and phytochemical extracts in relation to oxidative stress and inflammation

Articles

  • Special Issue
  • - Volume 2017
  • - Article ID 7658617
  • - Editorial

Antioxidant, Anti-Inflammatory, and Microbial-Modulating Activities of Nutraceuticals and Functional Foods

Ilaria Peluso | Thea Magrone | ... | Maura Palmery
  • Special Issue
  • - Volume 2017
  • - Article ID 6293740
  • - Research Article

Effect of Cocoa Polyphenolic Extract on Macrophage Polarization from Proinflammatory M1 to Anti-Inflammatory M2 State

Laura Dugo | Maria Giovanna Belluomo | ... | Anna Maria Sardanelli
  • Special Issue
  • - Volume 2017
  • - Article ID 9738745
  • - Research Article

Myricitrin Modulates NADPH Oxidase-Dependent ROS Production to Inhibit Endotoxin-Mediated Inflammation by Blocking the JAK/STAT1 and NOX2/p47phox Pathways

Shimei Qi | Zunyong Feng | ... | Yao Zhang
  • Special Issue
  • - Volume 2017
  • - Article ID 7503240
  • - Research Article

Development and In Vitro Evaluation of an Innovative “Dietary Flavonoid Supplement” on Osteoarthritis Process

Maria Rosaria Lauro | Lucia Crascí | ... | Giovanni Puglisi
  • Special Issue
  • - Volume 2017
  • - Article ID 8759764
  • - Research Article

Antigenotoxic Properties of Agaricus blazei against Hydrogen Peroxide in Human Peripheral Blood Cells

Lada Živković | Sunčica Borozan | ... | Biljana Spremo-Potparević
  • Special Issue
  • - Volume 2017
  • - Article ID 9315375
  • - Research Article

Influence of Synbiotics on Selected Oxidative Stress Parameters

Paulina Kleniewska | Rafał Pawliczak
  • Special Issue
  • - Volume 2017
  • - Article ID 7417505
  • - Research Article

Gut Microbiota in a Rat Oral Sensitization Model: Effect of a Cocoa-Enriched Diet

Mariona Camps-Bossacoma | Francisco J. Pérez-Cano | ... | Margarida Castell
  • Special Issue
  • - Volume 2017
  • - Article ID 8361493
  • - Research Article

A Chilean Berry Concentrate Protects against Postprandial Oxidative Stress and Increases Plasma Antioxidant Activity in Healthy Humans

Ines Urquiaga | Felipe Ávila | ... | Federico Leighton
  • Special Issue
  • - Volume 2017
  • - Article ID 9210862
  • - Research Article

Immune Profile of Obese People and In Vitro Effects of Red Grape Polyphenols on Peripheral Blood Mononuclear Cells

Thea Magrone | Emilio Jirillo | ... | Giovanni De Pergola
  • Special Issue
  • - Volume 2017
  • - Article ID 7384061
  • - Research Article

Antibacterial, Anti-Inflammatory, Antioxidant, and Antiproliferative Properties of Essential Oils from Hairy and Normal Roots of Leonurus sibiricus L. and Their Chemical Composition

Przemysław Sitarek | Patricia Rijo | ... | Tomasz Śliwiński
Oxidative Medicine and Cellular Longevity
 Journal metrics
Acceptance rate48%
Submission to final decision56 days
Acceptance to publication37 days
CiteScore7.300
Impact Factor5.076
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