While reactive oxygen species (ROS)/reactive nitrogen species (RNS) are important for normal cellular activities, deviant production of ROS, or diminished capacity to scavenge excessive ROS, leads to an imbalance in the redox environment of the cell. Given the dual role of ROS in normal cell functioning and maintaining homeostasis by clearance of excess ROS, indepth analysis of oxidative stress, under both normal and disease conditions will result in better understanding of disease-specific altered pathways. Additionally, mechanistic studies targeted towards deciphering regulation of cell-specific ROS in global gene expression, can illuminate the contribution of mitochondria and other cell organelles in the development of disease and may lead to the advancement of new and novel therapeutic modalities that exploit oxidative stress in treating many diseases.

We invite investigators to contribute original research as well as review articles that will stimulate the continuing efforts to understand the Janus of oxidative stress signaling. We are interested in articles which focus on altered cellular ROS or oxidative stress signaling in various pathophysiological conditions. Potential topics include, but are not limited to (oxidative stress could be related to reactive oxygen species/reactive nitrogen species):

• Oxidative stress/reactive oxygen species signaling
• Oxidative stress and mitochondrial signaling
• Endoplasmic reticulum stress
• Mitochondrial retrograde signaling
• Oxidative and reductive stress
• Therapeutic effects of controlling the ROS
• Pattern recognition receptors and ROS signaling
• ROS/oxidative stress in various pathophysiological conditions (diabetes, colitis, osteoporosis, aging, Alzheimer's disease, and toxicologically related diseases)

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/oximed/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/oximed/joss/ according to the following timetable: