Production of reactive oxygen species (ROS) is a consequence of aerobic metabolism which often results in heightened oxidative stress and pathophysiological implications in tissues and organ systems with a compromised antioxidant status. Excessive ROS generation depletes the endogenous antioxidant system that subsequently fails to counteract all the ROS leading to cellular injury. Alcohol consumption, high calorie diet, drugs, environmental pollutants, heavy metals, and so on have been implicated towards manifestation of liver injury via generation of intracellular oxidative stress. The mitochondria and endoplasmic reticulum of hepatocytes is the major source of ROS in various forms of liver diseases. Hence, free radical scavenging abilities of antioxidants are being tested for treating various diseases associated with oxidative stress including liver ailments. Although preclinical results are promising for antioxidant therapy in treating liver diseases, evidences obtained from clinical studies are unclear. Focused studies on management of oxidative stress in liver diseases will provide further insight into pathogenesis of hepatocyte injury and open new avenues for diagnosis and development of biomarkers and pharmacological therapies.

We invite investigators to submit original research and review articles on preclinical and clinical evaluation on the role of oxidative stress in liver diseases.

Potential topics include but are not limited to the following:

• Mechanisms for oxidative stress mediated acute and chronic liver damage
• Oxidative stress and pathogenesis of liver diseases
• Antioxidants as therapeutics in regulating liver injury
• Clinical reports on oxidative stress biomarkers for liver diseases
• microRNA mediated regulation of liver injury and oxidative stress
• Complementary and alternative therapies to reduce oxidative stress in liver