Oxidative Medicine and Cellular Longevity

Oxidative Stress in Liver Diseases: Pathogenesis, Prevention, and Therapeutics


Status
Published

1Augusta University, Augusta, USA

2M. S. University of Baroda, Gujarat, India

3University of Western Sydney, Sydney, Australia


Oxidative Stress in Liver Diseases: Pathogenesis, Prevention, and Therapeutics

Description

Production of reactive oxygen species (ROS) is a consequence of aerobic metabolism which often results in heightened oxidative stress and pathophysiological implications in tissues and organ systems with a compromised antioxidant status. Excessive ROS generation depletes the endogenous antioxidant system that subsequently fails to counteract all the ROS leading to cellular injury. Alcohol consumption, high calorie diet, drugs, environmental pollutants, heavy metals, and so on have been implicated towards manifestation of liver injury via generation of intracellular oxidative stress. The mitochondria and endoplasmic reticulum of hepatocytes is the major source of ROS in various forms of liver diseases. Hence, free radical scavenging abilities of antioxidants are being tested for treating various diseases associated with oxidative stress including liver ailments. Although preclinical results are promising for antioxidant therapy in treating liver diseases, evidences obtained from clinical studies are unclear. Focused studies on management of oxidative stress in liver diseases will provide further insight into pathogenesis of hepatocyte injury and open new avenues for diagnosis and development of biomarkers and pharmacological therapies.

We invite investigators to submit original research and review articles on preclinical and clinical evaluation on the role of oxidative stress in liver diseases.

Potential topics include but are not limited to the following:

  • Mechanisms for oxidative stress mediated acute and chronic liver damage
  • Oxidative stress and pathogenesis of liver diseases
  • Antioxidants as therapeutics in regulating liver injury
  • Clinical reports on oxidative stress biomarkers for liver diseases
  • microRNA mediated regulation of liver injury and oxidative stress
  • Complementary and alternative therapies to reduce oxidative stress in liver

Articles

  • Special Issue
  • - Volume 2017
  • - Article ID 8341286
  • - Editorial

Oxidative Stress in Liver Diseases: Pathogenesis, Prevention, and Therapeutics

Ravirajsinh N. Jadeja | Ranjitsinh V. Devkar | Srinivas Nammi
  • Special Issue
  • - Volume 2017
  • - Article ID 7841823
  • - Research Article

Hepatoprotective Effects of Antrodia cinnamomea: The Modulation of Oxidative Stress Signaling in a Mouse Model of Alcohol-Induced Acute Liver Injury

Yange Liu | Juan Wang | ... | Di Wang
  • Special Issue
  • - Volume 2017
  • - Article ID 1406726
  • - Research Article

Diallyl Trisulfide Suppresses Oxidative Stress-Induced Activation of Hepatic Stellate Cells through Production of Hydrogen Sulfide

Feng Zhang | Huanhuan Jin | ... | Shizhong Zheng
  • Special Issue
  • - Volume 2016
  • - Article ID 3269405
  • - Research Article

Proteomics-Based Identification of the Molecular Signatures of Liver Tissues from Aged Rats following Eight Weeks of Medium-Intensity Exercise

Fanghui Li | Tao Li | Yanying Liu
  • Special Issue
  • - Volume 2016
  • - Article ID 3453926
  • - Review Article

Naturally Occurring Nrf2 Activators: Potential in Treatment of Liver Injury

Ravirajsinh N. Jadeja | Kapil K. Upadhyay | ... | Sandeep Khurana
  • Special Issue
  • - Volume 2016
  • - Article ID 7962948
  • - Research Article

Endogenous n-3 Fatty Acids Alleviate Carbon-Tetrachloride-Induced Acute Liver Injury in Fat-1 Transgenic Mice

Ruibing Feng | Meng Wang | ... | Jian-Bo Wan
  • Special Issue
  • - Volume 2016
  • - Article ID 9895176
  • - Research Article

Liver Cholesterol Overload Aggravates Obstructive Cholestasis by Inducing Oxidative Stress and Premature Death in Mice

Natalia Nuño-Lámbarri | Mayra Domínguez-Pérez | ... | Luis Enrique Gomez-Quiroz
Oxidative Medicine and Cellular Longevity
 Journal metrics
Acceptance rate48%
Submission to final decision56 days
Acceptance to publication37 days
CiteScore7.300
Impact Factor5.076
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