Oxidative metabolism is a major source of oxidative stress and can impact all components of the cell, including DNA, proteins, and metabolites. Oxidative stress plays an essential role in the pathogenesis of chronic diseases such as cardiovascular diseases, diabetes, and neurodegenerative diseases. Although many studies report some metabolic impact of oxidative stress both at the cellular and organic level, very few focus on a global approach to metabolism, which is usually altered in these chronic diseases.

Metabolomics is an experimental approach that provides information on a wide range of molecular processes. Metabolomics can be considered, at the biochemical level, as the end of the “omic” cascade (from genomics, transcriptomics, proteomics, to metabolomics) since changes in the metabolome constitute the organism's last response to genetic, chemical, and environmental alterations. In this sense, the metabolome is closely linked to the phenotype and constitutes an extremely useful tool for evaluating physiological and pathophysiological states. Despite the obvious relationship between oxidative stress and metabolome, the literature about this intriguing connection is scarce.

The goal of this Special Issue is to understand the impact of oxidative stress in the metabolome in the context of chronic diseases, and to explore new associations and mechanisms for understanding the metabolic consequences of oxidative stress. Original research and review articles are welcome.

Potential topics include but are not limited to the following:

• The association between oxidative stress and metabolomic profiles
• Metabolic mechanisms for regulating oxidative stress
• Markers of oxidative stress in metabolomic studies
• Combined metabolomic and oxidative stress studies in aging