Oxidative stress results from an increased production of free radicals and reactive oxygen species (ROS), which causes severe damage to biological macromolecules and the dysregulation of normal metabolism and physiology.

Oxidative stress has been demonstrated to play a critical role on blood disorders including leukemia, anemia, lymphoma, hematopoietic stem cell transplantation, graft-versus-host disease and many more. As oxidative stress is involved in maintaining hematopoietic stem cells homeostasis, as well as in the progress of hemolytic anemia, immune thrombocytopenia and hematological malignancies like myelodysplastic syndrome, leukemia, et al., the redox products in the human body may be indicators to predict the outcome of these diseases and therefore may also be a target to treat them. Knowledge and understanding of these conditions have led to the development of animal models, successful therapies and novel tools to characterize these clinical conditions and provide better care to patients.

The aim of this Special Issue is to collate original research and review articles with a focus on the field of blood disorders resulting from oxidative stress. We are interested in articles that explore aspects of oxidative stress in blood disorders in both humans and animal models. Studies on lymphoma, leukemia, myelodysplastic syndrome, hematopoietic stem cell transplantation, radiation related blood disorders and myeloproliferative disease will be considered. A range of possible techniques will be considered, including but not limited to the indicative role of redox products in blood disorders.

Potential topics include but are not limited to the following:

• The role of oxidative stress in blood disorders
• New cellular and animal models to test and understand oxidative stress in blood disorders
• Role of oxidative stress in chemotherapy on blood disorders
• Role of oxidative stress in hematopoietic stem cell transplantation
• Role of oxidative stress in graft-versus-host disease
• Role of oxidative stress in sickle cells anemia