Oxidative Medicine and Cellular Longevity

Cellular and Molecular Mechanisms of Oxidative Stress in Wound Healing


Publishing date
01 Mar 2021
Status
Closed
Submission deadline
23 Oct 2020

1Universidade Federal de Viçosa, Viçosa, Brazil

2North Carolina State University, North Carolina, USA

This issue is now closed for submissions.
More articles will be published in the near future.

Cellular and Molecular Mechanisms of Oxidative Stress in Wound Healing

This issue is now closed for submissions.
More articles will be published in the near future.

Description

Wound healing is a process that requires a series of cellular and molecular interdependent events to restore tissue integrity after lesions. This process is mediated by growth factors, cytokines, resident and transitory cells, and is organized in phases involving inflammation, cell proliferation, and tissue remodeling. In the inflammatory phase, immune cells migrate to lesion areas to remove injured tissue and initiate the process of blood coagulation, which also promotes vascular hemostasis and releases chemotactic factors that stimulate the migration and activation of immune cells. In addition, during recovery of the injured area occurs leukocyte infiltration and releases proinflammatory cytokines, such as (IL1 and IL6), tumor necrosis factor-α and interferon gamma (IFN-γ).

Guided by these molecules, the proliferative stage progresses with intense cell proliferation and secretion of a provisory extra cellular matrix (ECM), covering the injured area with a highly vascularized and hydrated tissue. Apoptosis of most infiltrating leukocytes and down-regulation of pro-inflammatory mediators conduces to a remodeling process, which can evolve with tissue regeneration or healing. The remodeling phase corresponds mainly to changes in the extracellular matrix of the scar tissue, where most type III collagen fibers are progressively replaced by type I fibers, which are more resistant and abundant in intact skin.

Due to the complexity and interdependence of all phases of tissue repair, morphofunctional disturbances are not uncommon, especially when associated to metabolic (i.e., diabetes mellitus, vasculopathies) and microbial diseases (i.e., bacterial, fungal and parasitic infections). During inflammation, frequently cells release reactive oxygen (ROS) and nitrogen (RNS) species, which can lead to cell membrane disorganization and protein oxidation, consequently altering the cellular function. The balance between the production of pro-oxidant molecules and antioxidant effectors is important for efficient tissue repair. When the tissue is damaged, the inflammatory process triggers an intense production of radical and non-radical pro-oxidant mediators (i.e., OH•-, O2•-, H2O2, and NO), which are directly associated to lipid, protein and DNA oxidative damage that often culminates in disorganization of ECM and cell death. Therefore, a redox balance is necessary and contributes to create a molecular microenvironment favorable for stimulating fibroblast proliferation, migration, and activation, which culminates in adequate production and organization of ECM and a fast-wound closure.

This Special Issue aims to create an interdisciplinary platform involving morphological, physiological, biochemical, molecular, and pathological issues to discuss the relevance of the cellular and molecular mechanism of oxidative stress in wound healing. We welcome primary research articles and secondary studies that will illustrate and stimulate the continuing effort to understand the importance of cellular and molecular mechanisms in the repair of different morphological and/or functional disorders of target organs caused by physical, chemical, biological, and/or genetic processes.

Potential topics include but are not limited to the following:

  • Metabolism redox in wound healing
  • Biomarkers of oxidative stress and antioxidant defenses during wound healing
  • Therapies that act as antioxidants during the repair process
  • Analytical methods and instrumentation applied to the analysis of cell and molecular mechanisms in tissue repair
  • Main redox mechanisms involved in inflammatory processes during wound healing

Articles

  • Special Issue
  • - Volume 2021
  • - Article ID 4681041
  • - Research Article

Doxycycline Hyclate Modulates Antioxidant Defenses, Matrix Metalloproteinases, and COX-2 Activity Accelerating Skin Wound Healing by Secondary Intention in Rats

Luciana S. Altoé | Raul S. Alves | ... | Reggiani V. Gonçalves
  • Special Issue
  • - Volume 2021
  • - Article ID 8836058
  • - Research Article

Apelin/APJ-Manipulated CaMKK/AMPK/GSK3β Signaling Works as an Endogenous Counterinjury Mechanism in Promoting the Vitality of Random-Pattern Skin Flaps

Zhi-Ling Lou | Chen-Xi Zhang | ... | Qi-Feng Zhao
  • Special Issue
  • - Volume 2020
  • - Article ID 7305392
  • - Research Article

The Effects of Hypoxia-Reoxygenation in Mouse Digital Flexor Tendon-Derived Cells

Chen Chen | Wei Feng Mao | Ya Fang Wu
  • Special Issue
  • - Volume 2020
  • - Article ID 2459826
  • - Research Article

Effects of Strong Acidic Electrolyzed Water in Wound Healing via Inflammatory and Oxidative Stress Response

Ailyn Fadriquela | Ma Easter Joy Sajo | ... | Kyu-Jae Lee
  • Special Issue
  • - Volume 2020
  • - Article ID 8862953
  • - Research Article

What Is the Impact of Depletion of Immunoregulatory Genes on Wound Healing? A Systematic Review of Preclinical Evidence

Bárbara Cristina Félix Nogueira | Artur Kanadani Campos | ... | Reggiani Vilela Gonçalves
  • Special Issue
  • - Volume 2020
  • - Article ID 1682317
  • - Research Article

Were our Ancestors Right in Using Flax Dressings? Research on the Properties of Flax Fibre and Its Usefulness in Wound Healing

Tomasz Gębarowski | Benita Wiatrak | ... | Kazimierz Gąsiorowski
  • Special Issue
  • - Volume 2020
  • - Article ID 5618127
  • - Research Article

The Regenerative Potential of Donkey and Human Milk on the Redox-Sensitive and Proliferative Signaling Pathways of Skin Fibroblasts

H. Kocic | T. Langerholc | ... | U. Wollina
  • Special Issue
  • - Volume 2020
  • - Article ID 4103418
  • - Research Article

Antioxidant and Antimicrobial Potentials of Seed Oil from Carthamus tinctorius L. in the Management of Skin Injuries

Ikram Khémiri | Badiaa Essghaier | ... | Lotfi Bitri
  • Special Issue
  • - Volume 2020
  • - Article ID 4352761
  • - Review Article

Peptides from Animal Origin: A Systematic Review on Biological Sources and Effects on Skin Wounds

Raul Santos Alves | Levy Bueno Alves | ... | Reggiani Vilela Gonçalves
Oxidative Medicine and Cellular Longevity
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