Review Article
Nutrition and Healthy Ageing: Calorie Restriction or Polyphenol-Rich “MediterrAsian” Diet?
Table 2
Cellular localization, activity, and biological function of sirtuins 1–7 according to [
63].
| Sirtuin | Localization | Activity | Biological function |
| Sirt1 | Nucleus/cytosol | Deacetylase | Cell survival/metabolism | Sirt2 | Cytosol | Deacetylase | Cell cycle | Sirt3 | Mitochondria | Deacetylase | Thermogenesis/metabolism | Sirt4 | Mitochondria | ADP-ribosyltransferase | Insulin secretion/metabolism | Sirt5 | Mitochondria | Deacetylase | Unknown | Sirt6 | Nucleus | ADP-ribosyltransferase | DNA repair | Sirt7 | Nucleolus | Unknown | rDNA transcription |
|
|
ADP: adenosine diphosphate; rDNA: ribosomal desoxyribonucleic acid; Sirt: sirtuin.
|