Review Article
Nutrition and Healthy Ageing: Calorie Restriction or Polyphenol-Rich “MediterrAsian” Diet?
Table 4
Dietary restriction mimetics: mechanisms and side effects.
| Name of compound | Structure of compound | Mechanism of action | Side effects | References |
| Rapamycin/sirolimus | | Inhibition of mTor, induction of autophagy | Immunosuppression
| [93] | 2-Deoxy-D-glucose | | Inhibition of glucose metabolism | Cardiotoxicity | [94] | Metformin | | Inhibition of gluconeogenesis, stimulation of glucose uptake, inhibition of AMPK, and improvement of insulin sensitivity | Gastrointestinal complaints | [95–97] |
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