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Prostate Cancer
Volume 2011, Article ID 239460, 7 pages
Clinical Study

A Retrospective Study on Pathologic Features and Racial Disparities in Prostate Cancer

1Department of Pathology, University of Mississippi Medical Center, Jackson, MS 39216, USA
2Department of Surgery, University of Mississippi Medical Center, Jackson, MS 39216, USA

Received 10 July 2011; Revised 19 September 2011; Accepted 26 September 2011

Academic Editor: I. J. Powell

Copyright © 2011 Steven A. Bigler et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We reviewed more than 3,000 pathology reports on prostate cancer-related surgical specimens and analyzed racial disparities in histological and clinical features at the time of initial biopsy, diagnosis of prostate cancer, and prostatectomy, as well as in characteristics of tumor evolution between African American and Caucasian patients. As compared to Caucasians, African American patients had younger age, higher cancer detection rate, higher Gleason score of prostate cancer, and more bilateral involvement of the prostate. African Americans also had larger prostates, greater volume of tumor, and more positive margins. The diagnosis of HGPIN or ASAP in prostate biopsies and African American race conferred an increased risk of diagnosis of prostate cancer. The interval between prior noncancerous biopsy and the subsequent biopsy with diagnosis of prostate cancer was shorter in men with HGPIN, with ASAP, or of African American race.