Table of Contents Author Guidelines Submit a Manuscript
Prostate Cancer
Volume 2011 (2011), Article ID 301850, 7 pages
http://dx.doi.org/10.1155/2011/301850
Research Article

Proliferative Tumor Doubling Times of Prostatic Carcinoma

1Department of Pathology, University of Colorado Anschutz Medical Campus, P.O. Box 6511, Aurora, CO 80045, USA
2Medical Oncology, University of Colorado Anschutz Medical Campus, CO 80045, USA
3Radiation Oncology, University of Colorado Anschutz Medical Campus, CO 80045, USA
4Pharmacy Department, University of Colorado Anschutz Medical Campus, CO 80045, USA

Received 1 April 2011; Accepted 4 July 2011

Academic Editor: Kenneth A. Iczkowski

Copyright © 2011 Priya N. Werahera et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Prostate cancer (PCa) has a variable biology ranging from latent cancer to extremely aggressive tumors. Proliferative activities of cancers may indicate their biological potential. A flow cytometric assay to calculate maximum proliferative doubling times ( 𝑇 m a x ) of PCa in radical prostatectomy specimens after preoperative in vivo bromodeoxyuridine (BrdU) infusion is presented. Only 4/17 specimens had tumors large enough for flow cytometric analysis. The 𝑇 m a x of tumors was similar and ranged from 0.6 to 3.6 months. Tumors had calculated doubling times 2- to 25-fold faster than their matched normal tissue. Variations in labeling index and 𝑇 m a x were observed within a tumor as well as between different Gleason grades. The observed PSA doubling times (PSA-DT) ranged from 18.4 to 32.0 months, considerably slower than the corresponding 𝑇 m a x of tumors involved. While lack of data for apoptotic rates is a limitation, apparent biological differences between latent versus aggressive PCa may be attributable to variations in apoptotic rates of these tumors rather than their cell proliferative rates.