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Prostate Cancer
Volume 2011, Article ID 386207, 11 pages
Review Article

Beyond Diagnosis: Evolving Prostate Biopsy in the Era of Focal Therapy

Urology Department, Sunderland Royal Hospital, Kayll Road, Sunderland SR4 7TP, UK

Received 2 July 2010; Accepted 14 October 2010

Academic Editor: Alexandre R. Zlotta

Copyright © 2011 J. L. Dominguez-Escrig et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Despite decades of use as the “gold standard” in the detection of prostate cancer, the optimal biopsy regimen is still not universally agreed upon. While important aspects such as the need for laterally placed biopsies and the importance of apical cancer are known, repeated studies have shown significant patients with cancer on subsequent biopsy when the original biopsy was negative and an ongoing suspicion of cancer remained. Attempts to maximise the effectiveness of repeat biopsies have given rise to the alternate approaches of saturation biopsy and the transperineal approach. Recent interest in focal treatment of prostate cancer has further highlighted the need for accurate detection of prostate cancer, and in response, the introduction of transperineal template-guided biopsy. While the saturation biopsy approach and the transperineal template approach increase the detection rate of cancer in men with a previous negative biopsy and appear to have acceptable morbidity, there is a lack of clinical trials evaluating the different biopsy strategies. This paper reviews the evolution of prostatic biopsy and current controversies.