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Prostate Cancer
Volume 2011, Article ID 485189, 6 pages
Review Article

Prognostic Factors for the Development of Biochemical Recurrence after Radical Prostatectomy

Urology Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt

Received 28 February 2011; Revised 8 April 2011; Accepted 19 April 2011

Academic Editor: Kenneth A. Iczkowski

Copyright © 2011 Ahmed F. Kotb and Ahmed A. Elabbady. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Prostate cancer is one of the most common cancers in Western countries and is associated with a considerable risk of mortality. Biochemical recurrence following radical prostatectomy is a relatively common finding, affecting approximately 25% of cases. The aim of our paper was to identify factors that can predict the occurrence of biochemical recurrence, so the patient can be properly counselled pre- and postoperatively. Medline review of the literatures was done followed by a group discussion on the chosen publications and their valuable influence. Preoperative serum total PSA and clinical stage, together with prostatectomy Gleason grade, tumour volume, and perineural and vascular invasions, were the most important variables found to influence outcome.