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Prostate Cancer
Volume 2011 (2011), Article ID 895238, 22 pages
http://dx.doi.org/10.1155/2011/895238
Review Article

Mouse Models of Prostate Cancer

Van Andel Research Institute, 333 Bostwick Avenue N.E., Grand Rapids, MI 49503, USA

Received 10 August 2010; Revised 12 November 2010; Accepted 4 January 2011

Academic Editor: Craig Robson

Copyright © 2011 Kenneth C. Valkenburg and Bart O. Williams. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The development and optimization of high-throughput screening methods has identified a multitude of genetic changes associated with human disease. The use of immunodeficient and genetically engineered mouse models that mimic the human disease has been crucial in validating the importance of these genetic pathways in prostate cancer. These models provide a platform for finding novel therapies to treat human patients afflicted with prostate cancer as well as those who have debilitating bone metastases. In this paper, we focus on the historical development and phenotypic descriptions of mouse models used to study prostate cancer. We also comment on how closely each model recapitulates human prostate cancer.