Histone Deacetylase Inhibitors Restore Cell Surface Expression of the Coxsackie Adenovirus Receptor and Enhance CMV Promoter Activity in Castration-Resistant Prostate Cancer Cells

Figure 2

CAR expression and adenoviral infectivity. (a) Surface CAR expression was determined by flow cytometry. Mean fluorescence of cells stained with CAR antibody minus mean fluorescence of cells stained with the isotype control was determined. The average ± SD was calculated, and significance was determined using the student 𝑡-test. *𝑃<0.05, **𝑃<0.0005. (b) Adenoviral infectivity was determined by the expression of GFP 48 hours after transduction. All data shown are the mean ± SD from 3 independently performed experiments.

(a)

(b)