Histone Deacetylase Inhibitors Restore Cell Surface Expression of the Coxsackie Adenovirus Receptor and Enhance CMV Promoter Activity in Castration-Resistant Prostate Cancer Cells
Adenoviral infectivity and surface expression in 22Rv1 cells. (a) 22Rv1 cells were transduced with increasing amounts of AdGFP. The presence of GFP-positive cells was quantified by flow cytometry at 48 hrs after transduction. Data shown are the mean ± SD of an assay performed in duplicate. (b) Surface CAR expression was determined by flow cytometry (green = isotype, blue = anti-CAR, untreated cells, and red = anti-CAR in cells treated with 10 μM MS-275).
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