Growth and Progression of TRAMP Prostate Tumors in Relationship to Diet and Obesity

Table 3

Overview of NE status of TRAMP DIO study tumors.

Group	Percent NE positive	NE status	Initial body weight	Body weight increase (6–18 weeks)	Final body weight	Age at tumor detection	Age at death	GUT weight	High grade (%)
Obesity prone	37% (7/19)	Positive	20.8 ± 0.9	14.1 ± 0.6	39.1 ± 2.7	25.1^x±2.7	30.1^x±4.3	6.5^x±1.1	(100)^x 7/7
		Negative	20.8 ± 0.7	13.1 ± 0.4	43.9 ± 2.1	31.4 ± 0.9	46.3 ± 0.9	11.4 ± 0.9	(18) 2/11
Overweight	21% (3/14)	Positive	22.8 ± 1.1	9.5 ± 0.4	34.0^x±2.0	26.7^x±1.9	29.7^x±1.9	9.5 ± 0.8	(100) 2/2
		Negative	21.7 ± 0.5	9.5 ± 0.2	41.2 ± 1.2	33.7 ± 1.6	44.6 ± 1.5	9.9 ± 1.0	(56) 5/9
Obesity resistant	46% (6/13)	Positive	21.1 ± 0.5	7.2 ± 0.7	35.0 ± 2.7	26.7 ± 2.6	35.0 ± 4.6	7.7 ± 1.6	(100) 6/6
		Negative	22.3 ± 0.5	8.0 ± 0.2	40.6 ± 3.5	29.3 ± 1.6	42.1 ± 2.9	9.4 ± 10.5	(57) 4/7
All high-fat diet mice	35% (16/46)	Positive	21.3 ± 0.5	10.2 ± 0.8	36.6^x±1.6	26.0^x±1.5	31.9^x±2.5	8.5^x±0.7	(100)^x 15/15
		Negative	21.5 ± 0.3	11.0 ± 0.4	42.1 ± 1.2	31.8 ± 0.8	44.7 ± 0.9	10.4 ± 0.6	(41) 11/27
Low fat	35% (6/17)	Positive	19.7 ± 1.3	8.1 ± 1.8	36.6 ± 2.7	27.2^x±2.9	35.3^x±5.0	7.3^x±1.2	(100)^x 6/6
		Negative	21.2 ± 0.6	8.0 ± 0.7	39.7 ± 1.7	31.7 ± 1.2	45.8 ± 1.6	10.4 ± 1.0	(20) 2/10

A significant difference (𝑃<0.05) within each group is designated as ^x.