| Table 3: South African and Senegalese case-control genotype associations with prostate cancer (adjusted for age). |
| | Variables of interest | South Africa | Senegal | | White | Mixed | Black | Senegalese | | Genotypes | OR (95% CI) | OR (95% CI) | OR (95% CI) | OR (95% CI) |
| | CYP3A4 (rs2740574) | | | | | | AA | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | | AG | 3.32 (1.52–7.24)* | 3.38 (2.13–5.35)** | 0.21 (0.03–1.32) | 1.51 (0.52–4.38) | | GG | — | 4.57 (1.63–12.85) | — | 0.94 (0.54–1.65) | | AG/GG | 3.63 (1.68–7.84)* | 3.74 (2.37–5.89)** | 0.18 (0.03–1.16) | 1.13 (0.40–3.22) |
| | CYP3A5 (rs776746) | | | | | | GG | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | | AG | 1.14 (0.55–2.37) | 1.68 (1.02–2.76) | 1.31 (0.36–29.51) | 0.98 (0.18–5.39) | | AA | 1.14 (0.46–2.79) | 1.21 (0.89–1.64) | 1.65 (0.38–7.15) | 0.99 (0.50–1.99) | | AG/AA | 1.17 (0.59–2.32) | 1.61 (1.01–2.57) | 2.21 (0.12–39.39) | 0.98 (0.24–3.97) |
| SRD5A2 V89L
(rs523349) | | | | | | GG | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | | CG | 0.71 (0.41–1.24) | 0.74 (0.48–1.16) | 0.26 (0.04–1.54) | 0.36 (0.12–1.07) | | CC | 0.86 (0.49–1.50) | 0.78 (0.41–1.48) | 0.17 (0.04–0.66)* | 0.98 (0.60–1.59) | | CG/CC | 0.71 (0.41–1.22) | 0.73 (0.47–1.13) | 0.14 (0.03–0.66)* | 0.74 (0.30–1.86) |
| | SRD5A2 A49T (rs9282858) | | | | | | GG | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | | AG | 1.02 (0.54–1.95) | 2.31 (1.45–3.68)** | 0.43 (0.11–1.69) | — | | AA | — | — | — | — | | AG/AA | 1.02 (0.54–1.95) | 2.31 (1.45–3.68)** | 0.43 (0.11–1.69) | — |
|
|
—: too few/no genotypes to estimate ORs.
*
.
**
.
|