Androgen Metabolism Gene Polymorphisms, Associations with Prostate Cancer Risk and Pathological Characteristics: A Comparative Analysis between South African and Senegalese Men

Table 3

South African and Senegalese case-control genotype associations with prostate cancer (adjusted for age).

Variables of interest	South Africa			Senegal
	White	Mixed	Black	Senegalese
Genotypes	OR (95% CI)	OR (95% CI)	OR (95% CI)	OR (95% CI)
CYP3A4 (rs2740574)
AA	1.00 (ref)	1.00 (ref)	1.00 (ref)	1.00 (ref)
AG	3.32 (1.52–7.24)*	3.38 (2.13–5.35)**	0.21 (0.03–1.32)	1.51 (0.52–4.38)
GG	—	4.57 (1.63–12.85)	—	0.94 (0.54–1.65)
AG/GG	3.63 (1.68–7.84)*	3.74 (2.37–5.89)**	0.18 (0.03–1.16)	1.13 (0.40–3.22)
CYP3A5 (rs776746)
GG	1.00 (ref)	1.00 (ref)	1.00 (ref)	1.00 (ref)
AG	1.14 (0.55–2.37)	1.68 (1.02–2.76)	1.31 (0.36–29.51)	0.98 (0.18–5.39)
AA	1.14 (0.46–2.79)	1.21 (0.89–1.64)	1.65 (0.38–7.15)	0.99 (0.50–1.99)
AG/AA	1.17 (0.59–2.32)	1.61 (1.01–2.57)	2.21 (0.12–39.39)	0.98 (0.24–3.97)
SRD5A2 V89L; (rs523349)
GG	1.00 (ref)	1.00 (ref)	1.00 (ref)	1.00 (ref)
CG	0.71 (0.41–1.24)	0.74 (0.48–1.16)	0.26 (0.04–1.54)	0.36 (0.12–1.07)
CC	0.86 (0.49–1.50)	0.78 (0.41–1.48)	0.17 (0.04–0.66)*	0.98 (0.60–1.59)
CG/CC	0.71 (0.41–1.22)	0.73 (0.47–1.13)	0.14 (0.03–0.66)*	0.74 (0.30–1.86)
SRD5A2 A49T (rs9282858)
GG	1.00 (ref)	1.00 (ref)	1.00 (ref)	1.00 (ref)
AG	1.02 (0.54–1.95)	2.31 (1.45–3.68)**	0.43 (0.11–1.69)	—
AA	—	—	—	—
AG/AA	1.02 (0.54–1.95)	2.31 (1.45–3.68)**	0.43 (0.11–1.69)	—

—: too few/no genotypes to estimate ORs.
* 𝑃<0.05.
** 𝑃<0.0041.