Androgen Metabolism Gene Polymorphisms, Associations with Prostate Cancer Risk and Pathological Characteristics: A Comparative Analysis between South African and Senegalese Men
Table 3
South African and Senegalese case-control genotype associations with prostate cancer (adjusted for age).
Variables of interest
South Africa
Senegal
White
Mixed
Black
Senegalese
Genotypes
OR (95% CI)
OR (95% CI)
OR (95% CI)
OR (95% CI)
CYP3A4 (rs2740574)
AA
1.00 (ref)
1.00 (ref)
1.00 (ref)
1.00 (ref)
AG
3.32 (1.52–7.24)*
3.38 (2.13–5.35)**
0.21 (0.03–1.32)
1.51 (0.52–4.38)
GG
—
4.57 (1.63–12.85)
—
0.94 (0.54–1.65)
AG/GG
3.63 (1.68–7.84)*
3.74 (2.37–5.89)**
0.18 (0.03–1.16)
1.13 (0.40–3.22)
CYP3A5 (rs776746)
GG
1.00 (ref)
1.00 (ref)
1.00 (ref)
1.00 (ref)
AG
1.14 (0.55–2.37)
1.68 (1.02–2.76)
1.31 (0.36–29.51)
0.98 (0.18–5.39)
AA
1.14 (0.46–2.79)
1.21 (0.89–1.64)
1.65 (0.38–7.15)
0.99 (0.50–1.99)
AG/AA
1.17 (0.59–2.32)
1.61 (1.01–2.57)
2.21 (0.12–39.39)
0.98 (0.24–3.97)
SRD5A2 V89L (rs523349)
GG
1.00 (ref)
1.00 (ref)
1.00 (ref)
1.00 (ref)
CG
0.71 (0.41–1.24)
0.74 (0.48–1.16)
0.26 (0.04–1.54)
0.36 (0.12–1.07)
CC
0.86 (0.49–1.50)
0.78 (0.41–1.48)
0.17 (0.04–0.66)*
0.98 (0.60–1.59)
CG/CC
0.71 (0.41–1.22)
0.73 (0.47–1.13)
0.14 (0.03–0.66)*
0.74 (0.30–1.86)
SRD5A2 A49T (rs9282858)
GG
1.00 (ref)
1.00 (ref)
1.00 (ref)
1.00 (ref)
AG
1.02 (0.54–1.95)
2.31 (1.45–3.68)**
0.43 (0.11–1.69)
—
AA
—
—
—
—
AG/AA
1.02 (0.54–1.95)
2.31 (1.45–3.68)**
0.43 (0.11–1.69)
—
—: too few/no genotypes to estimate ORs.
*
.
**
.
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