Long-Term (10-Year) Gastrointestinal and Genitourinary Toxicity after Treatment with External Beam Radiotherapy, Radical Prostatectomy, or Brachytherapy for Prostate Cancer

Table 3

(a) Competing risk regression for late GU toxicity (≥2) for patients treated in 1999. (b) Competing risk regression for late GI toxicity (≥2) for patients treated with RT or PI in 1999 (𝑛=282).

(a)

Univariate analysis	𝑃 value	Hazard ratio	95% CI
Treatment
RP versus PI	0.73	1.21	0.41–3.55
RT versus PI	0.07	2.54	0.94–6.87
RT versus RP	0.06	2.11	0.97–4.59
Age (continuous variable)	0.12	1.04	0.99–1.10
Charlson score	0.52	1.09	0.84–1.42
Peripheral vascular disease (yes versus no)	0.42	1.81	0.43–7.62
Diabetes (yes versus no)	0.043	2.35	1.03–5.39
Androgen deprivation (yes versus no)	0.65	0.85	0.41–1.74
Body mass index	0.40	1.03	0.97–1.09

(b)

Univariate analysis	𝑃 value	Hazard ratio	95% CI
Treatment
EBRT versus BT	0.03	5.10	1.17–22.3
Age (continuous variable)	0.27	1.05	0.96–1.14
Charlson score	0.13	1.21	0.94–1.56
Peripheral vascular disease (yes versus no)	0.85	1.22	0.17–9
Diabetes (yes versus no)	0.0051	4.2	1.54–11.5
Androgen deprivation (yes versus no)	0.63	0.78	0.29–2.11
Body mass index	0.88	0.99	0.83–1.17
Multivariable analysis
Diabetes (yes versus no)	0.008	3.81	1.42–10.2
EBRT versus BT	0.038	4.71	1.09–20.3