Review Article
Postoperative Radiotherapy after Radical Prostatectomy: Indications and Open Questions
Table 2
Results of randomized trials on immediate adjuvant RT.
| Trial | SWOG 8794 | EORTC 22911 | ARO 96-02 |
| Overall survival | HR: 0.72 (95% CI 0.55–0.96),
| HR: 1.09 (98% CI 0.67–1.79),
| Not reported |
| bNED | HR: 0.43 (95% CI 0.31–0.58),
| HR: 0.48 (98% CI 0.37–0.62),
| HR: 0.53 (95% CI 0.37–0.79),
|
| Metastasis-free survival | HR: 0.71 (95% CI 0.54–0.94),
| Not reported | 98% versus 95.1 % (n.s.) |
| Clinical progression-free survival | HR: 0.62 (95% CI 0.46–0.82),
| HR: 0.61 (98% CI 0.43–0.87),
| Not reported |
| Time to initiation of hormonal therapy | HR: 0.45 (95% CI 0.29–0.68),
| Not reported | Not reported |
| Overall toxicity | 23.8% versus 11.9%,
| 4.2% versus 2.6% (Grade 3; ) | 21.9% versus 3.7%,
|
| Rectal toxicity | 3.3% versus 0%,
| Not reported | 1.4% versus 0% |
| Urinary stricture | 17.8% versus 9.5%,
| Not reported | Not reported |
| Total urinary incontinence | 6.5% versus 2.8%,
| Not reported | Not reported |
|
|
HR: hazard ratio; CI: confidence interval; n.s.: not significant.
|