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Prostate Cancer
Volume 2013, Article ID 103547, 11 pages
Review Article

Hypofractionated External-Beam Radiotherapy for Prostate Cancer

1University of Minnesota Medical Center, 420 Delaware Street SE, MMC-494, Minneapolis, MN 55455, USA
2Department of Radiation Oncology, University of Texas Southwestern Medical Center at Dallas, 5801 Forest Park Road, Dallas, TX 75390, USA
3Department of Radiation Oncology, University of Colorado School of Medicine, Anschutz Cancer Pavilion, Campus Mail Stop F-706, 1665 Aurora Court, Suite 1032, Aurora, CO 80045, USA

Received 30 April 2012; Accepted 13 October 2012

Academic Editor: Rami Ben-Yosef

Copyright © 2013 L. Chinsoo Cho et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


There are radiobiological rationales supporting hypofractionated radiotherapy for prostate cancer. The recent advancements in treatment planning and delivery allow sophisticated radiation treatments to take advantage of the differences in radiobiology of prostate cancer and the surrounding normal tissues. The preliminary results from clinical studies indicate that abbreviated fractionation programs can result in successful treatment of localized prostate cancer without escalation of late toxicity.