Table of Contents Author Guidelines Submit a Manuscript
Prostate Cancer
Volume 2014 (2014), Article ID 868269, 9 pages
Research Article

DWI of Prostate Cancer: Optimal -Value in Clinical Practice

1Department of Diagnostic Imaging and Interventional Radiology, Molecular Imaging and Radiotherapy, Fondazione Policlinico “Tor Vergata”, Viale Oxford 81, 00133 Rome, Italy
2Department of Biopathology and Image Diagnostics, Fondazione Policlinico “Tor Vergata”, Viale Oxford 81, 00133 Rome, Italy

Received 31 October 2013; Revised 3 January 2014; Accepted 3 January 2014; Published 18 February 2014

Academic Editor: Cristina Magi-Galluzzi

Copyright © 2014 Guglielmo Manenti et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Aim. To compare the diagnostic performance of diffusion weighted imaging (DWI) using -values of 1000 s/mm2 and 2000 s/mm2 at 3 Tesla (T) for the evaluation of clinically significant prostate cancer. Matherials and Methods. Seventy-eight prostate cancer patients underwent a 3T MRI scan followed by radical prostatectomy. DWI was performed using -values of 0, 1000, and 2000 s/mm2 and qualitatively analysed by two radiologists. ADC maps were obtained at -values of 1000 and 2000 s/mm2 and quantitatively analyzed in consensus. Results. For diagnosis of 78 prostate cancers the accuracy of DWI for the young reader was significantly greater at = 2000 s/mm2 for the peripheral zone (PZ) but not for the transitional zone (TZ). For the experienced reader, DWI did not show significant differences in accuracy between -values of 1000 and 2000 s/mm2. The quantitative analysis in the PZ and TZ was substantially superimposable between the two -values, albeit with a higher accuracy with a -value of 2000 s/mm2. Conclusions. With a -value of 2000 s/mm2 at 3T both readers differentiated clinical significant cancer from benign tissue; higher -values can be helpful for the less experienced readers.