Analysis of Prostate Cancer Susceptibility Variants in South African Men: Replicating Associations on Chromosomes 8q24 and 10q11

Table 2

Summary results for SNP genotyping analysis in South African men.

rs number	Cytoband	In/nearest gene^‡	Effect allele; frequency (); per effect allele OR (95% CI)^a; value (adjusted for age)
			Mixed Ancestry	White	Combined^b
rs9364554	6q25	SLC22A3	T; (); 0.236	T; (); 0.493	T; (); 0.737
rs10486567	7p15	JAZF1	G; (); 0.098	G; (); 1.89 (1.11–3.28); 0.019	G; (); 1.42 (1.08–1.85); 0.011
rs6465657	7q21	LMTK2	T; (); 0.56 (0.36–0.87); 0.010	T; (); 0.226	T; (); 0.455
rs7008482	8q24	NSMCE2	T; (); 0.41 (0.26–0.62);	G; (); 0.877	T; (); 0.48 (0.34–0.68);
rs6983561	8q24	PRNCR1	C; (); 0.335	C; (); 0.067	C; (); 0.078
rs6983267	8q24	POU5F1P1	T; (); 0.35 (0.23–0.53);	T; (); 0.774	T; (); 0.53 (0.39–0.73);
rs4242382	8q24	POU5F1P1	A; (); 0.59 (0.39–0.89); 0.013	A; (); 0.768	A; (); 0.11
rs10993994	10q11	MSMB	T; (); 1.56 (1.56–6.08);	T; (); 3.49 (2.28–5.54);	T; (); 2.09 (1.64–2.68);
rs4962416	10q26	CTBP2	C; (); 0.61 (0.36–0.97); 0.035	T; (); 0.305	T; (); 0.338
rs7931342	11q13	MYEOV	T; (); 0.064	T; (); 0.664	T; (); 0.091
rs4430796	17q12	HNF1B	A; (); 0.433	A; (); 0.48 (0.26–0.84); 0.010	A; (); 0.424
rs1859962	17q24	CASC17	G; (); 0.757	G; (); 1.42 (1.01–2.01); 0.044	G; (); 0.302
rs2735839	19q13	KLK3	A; (); 0.149	A; (); 0.734	A; (); 0.377

Only (Bonferroni correction) indicated in bold text was considered statistically significant.
^aOR (95% CI) only shown for SNPs where .
^bAdjusted for age and ethnicity.
^‡Genes indicated have been shown to be involved in prostate tumour onset or progression or to have altered expression in prostate tumours [34–41], except NSMCE2, shown to alter growth rates of breast cancer cells [42], MYEOV, shown to be overamplified in breast and oesophageal carcinomas [43], and CASC17, a long nonprotein coding RNA gene.