Table 1: Summary of prospective manuscripts studying relationship of acute and late GI toxicity after prostate RT.

Study name [citation]Study designToxicity analysis time pointsToxicity grading systemFollow-up durationAcute & late toxicity correlation
Acute endLate startAcuteChronic

Medical Research Council RT01 trial, Barnett et al. 2011 [12](i) Arm 1: 74 Gy/37 F () 3DCRT
(ii) Arm 2: 64 Gy/32 F () 3DCRT
6 W PTC2 Y PTCAcute RTOGLate RTOG, LENT/SOMA, UCLA-PCI, RMH Median not reported (2–5 Y)Yes

Arcangeli et al. 2011 [13](i) Arm 1: 80 Gy in 40 F () 3DCRT
(ii) Arm 2: 62 Gy in 20 F () 3DCRT
1 M PTC6 M PTCModified acute RTOGModified LENT/SOMA(i) Arm 1 median 32 M (8–66 M)
(ii) Arm 2 median 35 M (7–64 M)
Yes

Pinkawa et al. 2010 [14]70.2 or 72 Gy in 1.8–2.0 Gy/F (), 3DCRT6 M PTC12 M PTCExpanded Prostate Cancer Index Composite (EPIC)Expanded Prostate Cancer Index Composite (EPIC)Median 16 M (12–20 M) Yes

Kertesz et al. 2009 [15](i) 60–72 Gy, 1.8–2 Gy/F, (), 3DCRT
(ii) Unreported number on ADT
TRTAssume 90 D PTCCTC v2RTOG, LENT/SOMAMedian 50 M (9–59 M)Yes

Guckenberger et al. 2010 [16](i) 76.23 Gy/33 F () IMRT
(ii) 73.91 Gy/32 F () post prostatectomy IMRT
6 W PTC6 M PTCCTCAE v3.0CTCAE v3.0Median 26 MYes

AIROPROS 0102, Fellin et al. 2009 [17]70 Gy, 1.8–2 Gy/F (), 3DCRT1 M PTC6 M PTCCustom fecal incontinence and bleeding questionnaireCustom fecal incontinence and bleeding questionnaireMedian 36 M Yes

Koper et al. 2004 [18](i) 66 Gy in 2 Gy/F () 3DCRT
(ii) 66 Gy in 2 Gy/F () Conventional
(iii) 15% got adjuvant ADT
Assume 90 D PTC 1 Y PTC Acute RTOG, modified Tait, and Fransson questionnaireLate RTOG, modified Tait, and Fransson questionnaireMedian not reported, 93% followed to 2 YYes

Heemsbergen et al. 2006 [21](i) 68 Gy in 2 Gy/F () 3DCRT
(ii) 78 Gy in 2 Gy/F () 3DCRT
28 to 120 D PTC120 D PTCAcute RTOG, maximum score of acute mucous dischargeLate RTOGMedian 44 M Yes

Trans-tasman radiation oncology group, O’Brien et al. 2002 [19]52.5 Gy in 20 F () or 63–65 Gy in 2 Gy/F fractions (), conventionalAssume 90 D PTCAssume 90 D PTCAssume RTOG/EORTCRTOG/EORTC Median 63 MYes

Goineau et al. 2013 [20](i) 76 Gy in 38 F (), IMRT
(ii) ADT (6 M to 3 Y)
2 M PTC6 M PTCCTCAE V3, 
QLQ-C30, and QLQ-PR25
CTCAE V3, 
QLQ-C30, and QLQ-PR25
54 MNo

PTC = posttreatment completion, univariate (UV), multivariate (MV), androgen deprivation therapy (ADT), and TRT = throughout radiotherapy.
Acute RTOG = Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer acute morbidity rating scale.
Late RTOG = Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer late morbidity rating scale.
LENT = Late Effects Normal Tissue Task Force scale.
SOMA = Subjective, Objective, Management, and Analytic (SOMA) scales.
UCLA-PCI = University of California Loss Angeles Prostate Cancer Index.
RMH scale = Royal Marsden Hospital scale.
EPIC = Expanded Prostate Cancer Index Composite.
CTC v2 = Common Toxicity Criteria v2.0.
CTCAE V3 = Common Terminology Criteria for Adverse Events v3.0.
QLQ-C30 = EORTC QLQ-C30 quality of life questionnaire.
QLQ-PR25 = EORTC QLQ-PR25 quality of life questionnaire.
WHO = World Health Organization criteria.