Table 2: Summary of retrospective manuscripts studying relationship of acute and late GI toxicity after prostate RT.

Study name [citation]Study designToxicity analysis time pointsToxicity grading systemFollow-up durationAcute/late GI toxicity association
Acute endLate startAcuteChronic

Zilli et al. 2011 [23](i) IMRT 56 Gy in 4 Gy/F ()
(ii) Neoadjuvant ± concurrent ADT ()
6 W PTC6 M PTCAcute RTOGLate RTOG Median 48 M (9–67 M)No

Fiorica et al. 2010 [24](i) 78 Gy in 2 Gy/F, 3DCRT () 
(ii) 78 Gy in 2 Gy/F + 6 M AST, 3DCRT ()
TRT3 M PTCWHO SOMAMedian 35 M (9–88 M)No

Ballar et al. 2009 [25]74 Gy in 2 Gy/F, 3DCRT ()6 M PTC6 M PTCAcute RTOGLate RTOGMedian 30 M (20–50 M)No

Shu et al. 2001 [26]72.0 to 79.2 Gy, 3DCRT () or IMRT ()6 M PTC6 M PTCAcute RTOGLate RTOGMedian 23.1 M (10–84.7 M)No

Cahlon et al. 2008 [27](i) 86.4 Gy/48 F IMRT ()
(ii) Some had adjuvant 3–6 M ADT
90 D PTC 90 D PTCCTCAE V3CTCAE V3Media 53 M Yes

Zelefsky et al. 2008 [28](i) 66–81 Gy, 1.8 Gy/F, 3DCRT or IMRT ()
(ii) Neoadjuvant ADT 3 M ()
Assume 90 D PTCAssume 90 D PTCAssume
CTCAE V3
CTCAE V3 Median 8 Y (5–18 Y)Yes

Jereczek-Fossa et al. 2010 [30](i) Definitive RT 76 Gy in 2 Gy/F, 3DCRT ()
(ii) Postprostatectomy RT 70 Gy in 2 Gy/F, 3DCRT ()
3 M PTC3 M PTCAcute RTOGLate RTOGMedian 25.2 M (1–129 M)Yes

Liu et al. 2004 [22](i) Prospective database ()
(ii) 52.5–72 Gy in 20–36 F, conventional or 3DCRT
(iii) Neoadjuvant (), median duration (5.1 M), concurrent (), adjuvant (), and median duration (11 M)
Assume 90 D PTCAssume 90 D PTCAssume Acute RTOGModified RTOG/SOMAMedian 49 M (24–105 M)Yes

Zelefsky et al. 2008 [29] implantation (110 Gy) followed in 2 M by 50.4 Gy of IMRT in 1.8 Gy/F ()90 D PTC90 D PTCCTCAE CTCAEMedian 30 MNo

PTC = posttreatment completion, univariate (UV), multivariate (MV), androgen deprivation therapy (ADT), and TRT = throughout radiotherapy.
Acute RTOG = Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer acute morbidity rating scale.
Late RTOG = Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer late morbidity rating scale.
LENT = Late Effects Normal Tissue Task Force scale.
SOMA = Subjective, Objective, Management, and Analytic (SOMA) scales.
UCLA-PCI = University of California Loss Angeles Prostate Cancer Index.
RMH scale = Royal Marsden Hospital scale.
EPIC = Expanded Prostate Cancer Index Composite.
CTC v2 = Common Toxicity Criteria v2.0.
CTCAE V3 = Common Terminology Criteria for Adverse Events v3.0.
QLQ-C30 = EORTC QLQ-C30 quality of life questionnaire.
QLQ-PR25 = EORTC QLQ-PR25 quality of life questionnaire.
WHO = World Health Organization criteria.