Table of Contents Author Guidelines Submit a Manuscript
Prostate Cancer
Volume 2015, Article ID 728046, 8 pages
http://dx.doi.org/10.1155/2015/728046
Research Article

Thioredoxin 1 in Prostate Tissue Is Associated with Gleason Score, Erythrocyte Antioxidant Enzyme Activity, and Dietary Antioxidants

1Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA
2Roswell Park Cancer Institute, Buffalo, NY 14263, USA
3Epidemiology and Genomics Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD 20892, USA
4School of Public Health, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
5School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
6Department of Epidemiology and Biostatistics, Cancer Prevention and Control Program, University of South Carolina, Columbia, SC 29208, USA
7David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
8Department of Statistics, University of Connecticut, Storrs, CT 06269, USA

Received 16 April 2015; Accepted 29 July 2015

Academic Editor: Craig Robson

Copyright © 2015 Terrence M. Vance et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Prostate cancer is the most common noncutaneous cancer and second leading cause of cancer-related mortality in men in the US. Growing evidence suggests that oxidative stress is involved in prostate cancer. Methods. In this study, thioredoxin 1 (Trx 1), an enzyme and subcellular indicator of redox status, was measured in prostate biopsy tissue from 55 men from the North Carolina-Louisiana Prostate Cancer Project. A pathologist blindly scored levels of Trx 1. The association between Trx 1 and the Gleason score, erythrocyte antioxidant enzyme activity, and dietary antioxidant intake was determined using Fisher’s exact test. Results. Trx 1 levels in benign prostate tissue in men with incident prostate cancer were positively associated with the Gleason score () and inversely associated with dietary antioxidant intake (). In prostate cancer tissue, Trx 1 levels were associated with erythrocyte glutathione peroxidase activity (). No association was found for other erythrocyte enzymes. Greater Gleason score of malignant tissue corresponds to a greater difference in Trx 1 levels between malignant and benign tissue (). Conclusion. These results suggest that the redox status of prostate tissue is associated with prostate cancer grade and both endogenous and exogenous antioxidants.