Thioredoxin 1 in Prostate Tissue Is Associated with Gleason Score, Erythrocyte Antioxidant Enzyme Activity, and Dietary Antioxidants

Table 4

Association between prostate tissue Trx 1 and erythrocyte glutathione reductase (GR) activity.

	Erythrocyte glutathione reductase (GR)
	T1		T2		T3		Total
		%		%		%
Malignant Trx 1
0	2	(50)	1	(25)	1	(25)	4
1	0	(0)	3	(42)	4	(57)	7
2	9	(45)	6	(30)	5	(25)	20
3	3	(21)	6	(42)	5	(35)	14
Fisher’s exact test,
Benign Trx 1
0	0	(0)	0	(0)	1	(100)	1
1	7	(25)	13	(46)	8	(28)	28
2	5	(38)	2	(14)	6	(46)	13
3	2	(66)	1	(33)	0	(0)	3
Fisher’s exact test,
ΔTrx 1
−2	1	(50)	0	(0)	1	(50)	2
−1	1	(25)	2	(50)	1	(25)	4
0	6	(42)	4	(28)	4	(28)	14
1	5	(29)	5	(29)	7	(41)	17
2	1	(14)	5	(71)	1	(14)	7
3	0	(0)	0	(0)	1	(100)	1
Total	14		16		15		45
Fisher’s exact test,

ΔTrx 1: difference in Trx 1 level between malignant and benign prostate cells.
Median values of tertiles of GR activity are as follows: T1: 137.8 mol/min/mL; T2: 205.8 nmol/min/mL; T3: 383.8 nmol/min/mL.