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Prostate Cancer
Volume 2017 (2017), Article ID 5687212, 7 pages
Research Article

Biomarkers of Prostatic Cancer: An Attempt to Categorize Patients into Prostatic Carcinoma, Benign Prostatic Hyperplasia, or Prostatitis Based on Serum Prostate Specific Antigen, Prostatic Acid Phosphatase, Calcium, and Phosphorus

1Department of Biochemistry, Owaisi Group of Hospitals, DCMS, Hyderabad, Telangana, India
2Department of Urology, Owaisi Group of Hospitals, DCMS, Hyderabad, Telangana, India
3Salar-e-Millat Research Centre, PEH, DCMS, Hyderabad, Telangana, India

Correspondence should be addressed to Mohammed Abdul Majid Adil

Received 17 May 2016; Revised 24 August 2016; Accepted 25 October 2016; Published 12 January 2017

Academic Editor: Weide Zhong

Copyright © 2017 Shahana Sarwar et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Prostatitis, BPH, and P.Ca are the most frequent pathologies of the prostate gland that are responsible for morbidity in men. Raised levels of PSA are seen in different pathological conditions involving the prostate. PAP levels are altered in inflammatory or infectious or abnormal growth of the prostate tissue. Serum calcium and phosphorus levels were also found to be altered in prostate cancer and BPH. The present study was carried out to study the levels of PSA, PAP, calcium, and phosphorus in serum of patients with Prostatitis, BPH, or P.Ca and also to evaluate the relationship between them. Males in the age group of 50–85 years with LUTS disease symptoms and with PSA levels more than 4 ng/mL were included. A total of 114 patients were analyzed including 30 controls. Prostatitis in 35.7% of cases, BPH in 35.7% of the cases, and P.Ca in 28.57% of the cases were observed. Thus, the nonmalignant cases constitute a majority. PSA, a marker specific for prostatic conditions, was significantly high in all the diseases compared to controls. A rise in serum PSA and PAP indicates prostatitis or, in combination with these two tests, decreased serum calcium shows advanced disease.