Biomarkers of Prostatic Cancer: An Attempt to Categorize Patients into Prostatic Carcinoma, Benign Prostatic Hyperplasia, or Prostatitis Based on Serum Prostate Specific Antigen, Prostatic Acid Phosphatase, Calcium, and Phosphorus

Table 3

The sensitivity and specificity of various biomarkers in different groups are given in the table.

Parameter		Control versus total	Prostatitis versus BPH	BPH versus P.Ca	Prostatitis versus P.Ca
PSA (ng/mL)	Best cutoff	4.75	16.75	22.5	36.3
	Sensitivity	100	70	99.2	70.8
	Specificity	100	83.3	96.2	50
PAP (IU/L)	Best cutoff	4.05	6.35	10.5	19.5
	Sensitivity	76.2	90	87.5	79.2
	Specificity	96.7	90	100	93
Calcium (mg/dL)	Best cutoff	8.95	10.6	5.8	5.8
	Sensitivity	47.6	6.7	100	100
	Specificity	63.3	100	0	0
Phosphorus (mg/dL)	Best cutoff	4.35	6.65	5.55	3.1
	Sensitivity	42.9	99.9	4.25	70.8
	Specificity	93.3	96.3	86.7	40

The table shows the sensitivity and specificity pattern of PSA and PAP in different groups. At BCV 4.75 ng/mL, the PSA showed 100% sensitivity and specificity whereas at BCV 4.05 IU/L PAP showed 76.2% sensitivity and 96.7% specificity. BCV at 5.8 mg/dL calcium showed 100% sensitivity in BPH versus P.Ca and prostatitis versus P.Ca.