Table 1: List of the 34-gene signature containing the most highly somatically mutated genes (≥ 5 Mutation events) that were significantly differentially expressed between aggressive tumors and controls.

GenesRegionMutation eventsDE P value

SPOP17q21.33292.13E-25
ATM11q22.3130.004526
FOXA114q21.1121.41E-31
KMT2C7q36.1120.04799
LRP1B2q22.1105.18E-31
FAT311q14.391.69E-39
OBSCN1q42.1397.66E-05
FREM213q13.384.60E-12
CSMD38q23.380.000312
KIF16B20p12.180.020567
PCDH184q28.372.00E-15
SYNE16q25.271.12E-07
AHNAK11q12.376.32E-06
PLCB420p12.370.000102
FAT25q33.162.13E-31
FAM83B6p12.168.65E-31
DCHS24q31.364.08E-27
CDH2310q22.161.01E-26
MACF11p34.369.90E-06
FLG1q21.362.97E-05
PIK3CA3q26.3263.39E-05
VPS13D1p36.2264.42E-05
HFM11p22.260.003362
PTPRD9p24.160.017381
EPHB13q22.259.49E-41
KIAA16141q25.356.36E-26
AHNAK214q32.3358.04E-26
MXRA5Xp22.3352.48E-07
SACS13q12.1257.04E-07
ASH1L1q2256.85E-05
RYR21q4358.91E-05
CTNNB13p22.150.000345
MT-ND521q22.350.014434
FZD411q14.250.042185

Note. DE indicates differential expression. indicates genes associated with aggressive PCa.