Prostate Cancer / 2019 / Article / Tab 2 / Research Article
Interactions between Germline and Somatic Mutated Genes in Aggressive Prostate Cancer Table 2 List of the 61-gene signature containing both germline and somatic mutations found to be significantly differentially expressed between aggressive tumors and controls.
indicates the gene containing genetic variants directly associated with aggressive PCa.
ā GWAS DE Genes Chrom SNP_ID P valueGermline Somatic P valuePGBD1 6p22.1 rs1233708 0.004 1 2 0.02169 OXR1 8q23 rs16901979 0.002 1 1 1.52E-20 GZF1 20p11.21 rs6076072 0.01 1 1 2.42E-12 ITGAX 16p11.2 rs8045738 0.006 1 1 1.20E-11 ORC3 6q15 rs9450716 0.002 1 1 3.31E-06 BMPR1B 4q22 rs17021918 0.03 1 1 3.17E-06 KLK3 19q13.41 rs2739472 9.00E-186 15 1 4.43E-13 KLK2 19q13.33 rs1354774 6.00E-20 5 1 4.53E-19 NKX3-1 8p21.2 rs13272392 4.00E-34 4 1 3.30E-20 SLC22A3 6q25.3 rs4646284 3.20E+52 4 1 6.62E-11 RNASEL 1q25 rs486907 0.004 3 1 8.88E-26 ZNF827 4q31.22 rs56935123 4.00E-09 2 3 9.16E-06 FGFR2 10q26.12 rs10886902 2.00E-53 2 1 8.24E-29 HOXB13 8q24.21 rs188140481 6.00E-34 2 1 2.36E-27 PDLIM5 4q22 rs17021918 4.20E-15 2 1 1.36E-21 POU5F1B 8q24.21 rs16901979 1.00E-16 2 1 4.94E-17 SLC19A2 1q23.3 rs3765227 1.26E-04 2 1 6.46E-11 ITGA6 2q31.1 rs126212278 0.001 2 1 5.56E-10 TBX5 12q24.1 rs1270884 6.75E-11 2 1 1.53E-09 SLC41A1 1q32.1 rs6679073 4.00E-15 2 1 0.026695 LRP1B 2q21.2 rs10210358 2.00E-06 1 10 7.28E-33 PKHD1 6p21.2 rs10498792 3.00E-06 1 4 0.01337 ATF7IP 12p13.1 rs3213764 2.00E-09 1 3 1.13E-06 FREM1 9p22.3 rs1552895 0.002 1 3 7.30E-05 BCL11A 2p16.1 rs2556375 6.00E-19 1 2 2.02E-17 SIX1 14q23.1 rs7153648 2.00E-09 1 2 4.77E-16 DNAH5 5p15.2 rs4463179 2.00E-06 1 2 8.71E-16 PRDM15 21q22.3 rs6586243 7.79E-06 1 2 6.34E-13 GLI2 2q14 rs11122834 5.00E-06 1 2 1.28E-11 TRIM31 6p22.1 rs115457135 1.00E-07 1 2 4.61E-11 TCF7L2 10q25.3 rs7903146 0.009 1 2 1.43E-08 KIAA1211 4q12 rs629242 7.25E-07 1 2 5.48E-06 MDM4 1q32 rs4245739 2.01E-11 1 2 9.95E-05 TBX3 12q24.21 rs11067228 1.00E-14 1 2 0.000208 LMTK2 7q22.1 rs6465657 0.007 1 2 0.00243 STAT3 17q21 rs744166 0.03 1 2 0.002775 IL16 15q26.3 rs7175701 9.80E-08 1 2 0.026789 EPHA10 1p34.3 rs731174 5.00E-06 1 1 1.44E-35 FERMT2 14q22.1 rs8008270 1.78E-14 1 1 3.20E-30 FTO 16q12.2 rs9939609 0.04 1 1 6.96E-16 BMPR1A 10q22.3 rs11597689 0.03 1 1 1.09E-13 EIF2S3 Xp22.11 rs6627995 1.00E-13 1 1 1.21E-12 TTC7A 2p16.3 rs10194115 5.00E-07 1 1 1.81E-11 NAALADL2 3q26.31 rs78943174 4.00E-08 1 1 4.07E-10 PPFIBP2 11p15.4 rs12791447 4.00E-08 1 1 5.20E-10 KCNN3 1q21.3 rs1218582 1.95E-08 1 1 9.96E-10 AMIGO2 12q13.11 rs2711721 2.00E-06 1 1 2.17E-09 ZNF652 17q21.32 rs7210100 3.40E-13 1 1 5.55E-09 MYO6 6q14.1 rs9443189 4.00E-08 1 1 2.71E-08 EBF2 8p21.2 rs11135910 8.00E-11 1 1 8.98E-08 TBX1 22q11.21 rs2238776 2.00E-08 1 1 7.97E-08 PTGFRN 1p13.1 rs2806864 6.00E-07 1 1 2.52E-07 TNC 9q33.1 rs7847271 4.00E-06 1 1 3.93E-07 ATP9B 18q23 rs7241993 2.00E-09 1 1 4.37E-06 HAPLN1 5q14.3 rs4466137 3.00E-06 1 1 6.25E-05 NOTCH4 6p21.3 rs3096702 4.78E-09 1 1 5.81E-05 VGLL3 3p12.1 rs9757252 5.00E-06 1 1 7.72E-05 IKZF2 2q13.1 rs7569918 8.85E-04 1 1 9.51E-05 KLF4 9q31.2 rs817826 5.00E-14 1 1 0.002599 TNS3 7p12.3 rs56232506 9.00E-09 1 1 0.007265 DDHD1 14q22.1 rs8008270 2.00E-14 1 1 0.008911
Note. DE indicates differential expression.