Table 2: List of the 61-gene signature containing both germline and somatic mutations found to be significantly differentially expressed between aggressive tumors and controls. indicates the gene containing genetic variants directly associated with aggressive PCa.

GWASDE
GenesChromSNP_IDP valueGermlineSomaticP value

PGBD16p22.1rs12337080.004120.02169
OXR18q23rs169019790.002111.52E-20
GZF120p11.21rs60760720.01112.42E-12
ITGAX16p11.2rs80457380.006111.20E-11
ORC36q15rs94507160.002113.31E-06
BMPR1B4q22rs170219180.03113.17E-06
KLK319q13.41rs27394729.00E-1861514.43E-13
KLK219q13.33rs13547746.00E-20514.53E-19
NKX3-18p21.2rs132723924.00E-34413.30E-20
SLC22A36q25.3rs46462843.20E+52416.62E-11
RNASEL1q25rs4869070.004318.88E-26
ZNF8274q31.22rs569351234.00E-09239.16E-06
FGFR210q26.12rs108869022.00E-53218.24E-29
HOXB138q24.21rs1881404816.00E-34212.36E-27
PDLIM54q22rs170219184.20E-15211.36E-21
POU5F1B8q24.21rs169019791.00E-16214.94E-17
SLC19A21q23.3rs37652271.26E-04216.46E-11
ITGA62q31.1rs1262122780.001215.56E-10
TBX512q24.1rs12708846.75E-11211.53E-09
SLC41A11q32.1rs66790734.00E-15210.026695
LRP1B2q21.2rs102103582.00E-061107.28E-33
PKHD16p21.2rs104987923.00E-06140.01337
ATF7IP12p13.1rs32137642.00E-09131.13E-06
FREM19p22.3rs15528950.002137.30E-05
BCL11A2p16.1rs25563756.00E-19122.02E-17
SIX114q23.1rs71536482.00E-09124.77E-16
DNAH55p15.2rs44631792.00E-06128.71E-16
PRDM1521q22.3rs65862437.79E-06126.34E-13
GLI22q14rs111228345.00E-06121.28E-11
TRIM316p22.1rs1154571351.00E-07124.61E-11
TCF7L210q25.3rs79031460.009121.43E-08
KIAA12114q12rs6292427.25E-07125.48E-06
MDM41q32rs42457392.01E-11129.95E-05
TBX312q24.21rs110672281.00E-14120.000208
LMTK27q22.1rs64656570.007120.00243
STAT317q21rs7441660.03120.002775
IL1615q26.3rs71757019.80E-08120.026789
EPHA101p34.3rs7311745.00E-06111.44E-35
FERMT214q22.1rs80082701.78E-14113.20E-30
FTO16q12.2rs99396090.04116.96E-16
BMPR1A10q22.3rs115976890.03111.09E-13
EIF2S3Xp22.11rs66279951.00E-13111.21E-12
TTC7A2p16.3rs101941155.00E-07111.81E-11
NAALADL23q26.31rs789431744.00E-08114.07E-10
PPFIBP211p15.4rs127914474.00E-08115.20E-10
KCNN31q21.3rs12185821.95E-08119.96E-10
AMIGO212q13.11rs27117212.00E-06112.17E-09
ZNF65217q21.32rs72101003.40E-13115.55E-09
MYO66q14.1rs94431894.00E-08112.71E-08
EBF28p21.2rs111359108.00E-11118.98E-08
TBX122q11.21rs22387762.00E-08117.97E-08
PTGFRN1p13.1rs28068646.00E-07112.52E-07
TNC9q33.1rs78472714.00E-06113.93E-07
ATP9B18q23rs72419932.00E-09114.37E-06
HAPLN15q14.3rs44661373.00E-06116.25E-05
NOTCH46p21.3rs30967024.78E-09115.81E-05
VGLL33p12.1rs97572525.00E-06117.72E-05
IKZF22q13.1rs75699188.85E-04119.51E-05
KLF49q31.2rs8178265.00E-14110.002599
TNS37p12.3rs562325069.00E-09110.007265
DDHD114q22.1rs80082702.00E-14110.008911

Note. DE indicates differential expression.